Reduction in added sugar intake and improvement in insulin secretion in overweight latina adolescents
Reduction in added sugar intake and improvement in insulin secretion in overweight latina adolescents
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DOI：
10.1089/met.2006.0038
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发表时间：
2007-06-01
影响因子：
2.1
通讯作者：
Goran, Michael I.
中科院分区：
文献类型：
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作者：
Davis, Jaimie N.;Ventura, Emily E.;Goran, Michael I.
背景：到目前为止，还没有研究评估改变碳水化合物摄入量(特别是减少添加糖和增加纤维)对胰岛素分泌的影响，也没有任何研究使用超重的拉丁裔青少年人口。这项研究的目的是检验在12周的改良碳水化合物饮食干预后，饮食摄入量的变化，特别是添加糖的减少和/或纤维的增加，是否与胰岛素分泌的变化和2型糖尿病的其他代谢危险因素有关。方法：参与者是16名超重(>；=85%BMI)的拉丁裔青春期女性(12-17岁)，她们完成了为期12周的改良碳水化合物干预。饮食摄入量通过3天的饮食记录进行评估，身体成分通过双能X线吸收测量仪进行评估，胰岛素动力学通过扩展的3小时口服葡萄糖耐量试验进行评估。结果：报告的添加糖摄入量(占KCAL的百分比)的未经调整的变化与胰岛素分泌的变化(即IAUC)有关联的趋势(r=0.47；p=0.075)，在控制了年龄、基线胰岛素分泌、添加糖和肥胖以及肥胖的变化后，这种关系变得显著(r=0.85p<；0.05)。饮食变量的其他变化与胰岛素分泌的变化或2型糖尿病的其他代谢危险因素无关。结论：添加糖摄入量减少较多的参与者在经过改进的碳水化合物营养干预后，胰岛素分泌有显著改善。这些发现表明，以减少额外糖摄入量为重点的干预措施有可能降低超重青年患2型糖尿病的风险。
Background: To date, no study has assessed the effects of modifying carbohydrate intake (specifically decreasing added sugar and increasing fiber) on insulin secretion, nor has any study used an overweight Latino adolescent population. The objective of this study was to examine whether changes in dietary intake, specifically reductions in added sugar and/or increases in fiber, following a 12-week, modified carbohydrate dietary intervention, were associated with changes in insulin secretion and other metabolic risk factors for type 2 diabetes.Methods: Participants were 16 overweight (>= 85th percentile BMI) Latina adolescent females (12-17 years) who completed a 12-week modified carbohydrate intervention. Dietary intake was assessed by 3-day diet records, body composition by dual-energy X-ray absorptiometry, and insulin dynamics by an extended 3-hour oral glucose tolerance test (OGTT) at baseline and postintervention.Results: There was a trend for unadjusted change in reported added sugar intake (% of kcals) to be associated with change in insulin secretion, i.e. IAUC (r = 0.47; p = 0.075), and this relationship became significant after controlling for age, baseline insulin secretion, added sugar and adiposity, and change in adiposity (r = 0.85; p < 0.05). No other changes in dietary variables were related to changes in insulin secretion or other metabolic risk factors for type 2 diabetes.Conclusions: Participants with greater reductions in added sugar intake showed significantly greater improvements in insulin secretion following a modified carbohydrate nutrition intervention. These findings suggest that interventions focused on decreasing added sugar intake have the potential to reduce type 2 diabetes risk in overweight youth.