A new prognostic indicator for head and neck cancer--p53 serum antibodies?
A new prognostic indicator for head and neck cancer--p53 serum antibodies?
复制标题
头颈癌新的预后指标——p53血清抗体？
作者：
S. Gottschlich;Benedikt J. Folz;T. Goeroegh;B. M. Lippert;J. Maass;Jochen A. Werner
背景
p53抗体是一种新的血清学参数，在恶性肿瘤患者中的潜力未知。它们的发生已经在各种类型的癌症患者中描述，并且在头颈癌患者和其他癌症患者群体中的几项研究已经表明其预后价值。
材料和方法
我们调查了271例头颈癌患者的p53血清抗体的发生率与ELISA和调查可能的相关性与临床参数，如肿瘤分期和分级。
结果
67例（24.7%）头颈部肿瘤患者血清p53抗体阳性。p53抗体状态与肿瘤分期和分级之间无相关性。
结论
这些结果表明，p53抗体的发生并不相关的最相关的预后因素，区域转移率和原发肿瘤的大小，在头颈癌患者。
BACKGROUND
p53 antibodies are a new serological parameter of unknown potential in patients with malignancies. Their occurrence has been described in various types of cancer patients and several studies in head and neck cancer patients and other cancer patient groups have indicated its prognostic value.
MATERIAL AND METHODS
We investigated the incidence of p53 serum antibodies in 271 head and neck cancer patients with an ELISA and investigated a possible correlation with clinical parameters like tumor staging and grading.
RESULTS
Sixty-seven head and neck cancer patients (24.7%) were seropositive for p53 antibodies. No correlation between p53 antibody status, tumor staging and grading was found.
CONCLUSIONS
These results indicate that the occurrence of p53 antibodies does not correlate with the most relevant prognostic factors, rate of regional metastasis and primary tumor size, in patients with head and neck cancer.
影响因子：
10.3
作者：
Rosenfeld, MR;Malats, N;Dalmau, J
通讯作者：
Dalmau, J
影响因子：
56.9
作者：
HOLLSTEIN, M;SIDRANSKY, D;HARRIS, CC
通讯作者：
HARRIS, CC