Hypertensive Kidney Injury and the Progression of Chronic Kidney Disease.
Hypertensive Kidney Injury and the Progression of Chronic Kidney Disease.
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DOI：
10.1161/hypertensionaha.117.08314
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发表时间：
2017-10
期刊：
影响因子：
--
通讯作者：
Griffin KA
中科院分区：
文献类型：
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作者：
Griffin KA
688 高血压 2017 年 10 月 HIRD 易感性临床模式如图 1 所示，涉及 HIRD 的血压阈值以及血压与 HIRD 之间关系的斜率。病理模式也相似。尽管高血压严重，但 SHR 和 SHRsp 均显示出最小的组织学损伤和蛋白尿。补充盐会增加两者的血压，但对盐敏感的 SHRsp 的血压会增加，从而超过恶性肾硬化的临界阈值。相比之下，在 CKD 模型中，肾小球硬化和蛋白尿在低得多的血压阈值下发生，并随着血压的升高而线性增加。除严重高血压动物外，通常不会观察到血管损伤。
688 Hypertension October 2017 clinical patterns of HIRD susceptibility schematically illustrated in Figure 1 with respect to the BP threshold for HIRD and the slopes of the relationship between BP and HIRD. The pathological patterns are also similar. Both the SHR and SHRsp show minimal histological injury and proteinuria despite substantial hypertension. Salt supplementation increases the BP in both but more so in the salt-sensitive SHRsp such that the critical threshold for malignant nephrosclerosis is exceeded. By contrast, glomerulosclerosis and proteinuria develop at a much lower BP threshold in the CKD model and increase linearly with increasing BP. Vascular injury is usually not observed except in severely hypertensive animals.