Prospects for the Mechanism of Spiroplasma Swimming.
Prospects for the Mechanism of Spiroplasma Swimming.
复制标题
DOI：
10.3389/fmicb.2021.706426
复制
发表时间：
2021
影响因子：
5.2
通讯作者：
Miyata M
中科院分区：
文献类型：
--
作者：
Sasajima Y;Miyata M
螺旋体是一种缺乏肽聚糖层的螺旋细菌。它们作为节肢动物和植物的寄生虫在全球范围内广泛传播。它们的感染过程和生存很可能是由它们独特的游泳系统支持的，而这与众所周知的细菌运动系统如鞭毛和菌毛无关。螺旋体通过交替地从细胞前方交换左旋和右旋螺旋细胞体来游泳。螺旋度变化产生的扭结沿着细胞轴向下移动，像螺丝一样在扭结位置后面旋转细胞体，将水向后推，推动细胞体向前。为了阐明细胞螺旋性的形成和游动的机制，一个被称为“带状”的内部结构已经成为焦点。丝带由螺旋体特异的纤毛蛋白和细菌肌动蛋白MreB组成。在这里，我们提出了一种聚焦于丝带的螺旋度转换游泳模型，在该模型中，Mrebs基于ATP能量产生类似双金属条的力，并切换螺旋原纤丝的手性。这些细丝的协同变化导致螺旋度向细胞轴下移。有趣的是，与其他运动系统不同，纤维蛋白和螺旋体Mrebs可以追溯到它们的祖先。纤维蛋白是由甲硫腺苷/S-腺苷同型半胱氨酸核苷酶和Mrebs进化而来的，甲硫腺苷/S同型半胱氨酸是生长所必需的，Mrebs是壁细菌合成肽聚糖的支架。
Spiroplasma are helical bacteria that lack a peptidoglycan layer. They are widespread globally as parasites of arthropods and plants. Their infectious processes and survival are most likely supported by their unique swimming system, which is unrelated to well-known bacterial motility systems such as flagella and pili. Spiroplasma swims by switching the left- and right-handed helical cell body alternately from the cell front. The kinks generated by the helicity shift travel down along the cell axis and rotate the cell body posterior to the kink position like a screw, pushing the water backward and propelling the cell body forward. An internal structure called the “ribbon” has been focused to elucidate the mechanisms for the cell helicity formation and swimming. The ribbon is composed of Spiroplasma-specific fibril protein and a bacterial actin, MreB. Here, we propose a model for helicity-switching swimming focusing on the ribbon, in which MreBs generate a force like a bimetallic strip based on ATP energy and switch the handedness of helical fibril filaments. Cooperative changes of these filaments cause helicity to shift down the cell axis. Interestingly, unlike other motility systems, the fibril protein and Spiroplasma MreBs can be traced back to their ancestors. The fibril protein has evolved from methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase, which is essential for growth, and MreBs, which function as a scaffold for peptidoglycan synthesis in walled bacteria.
登录
查看更多内容
探索Spiroplasma Biology：机遇和挑战。
影响因子：
5.2
作者：
Harne S;Gayathri P;Béven L
通讯作者：
Béven L
影响因子：
4.5
作者：
Grosjean H;Breton M;Sirand-Pugnet P;Tardy F;Thiaucourt F;Citti C;Barré A;Yoshizawa S;Fourmy D;de Crécy-Lagard V;Blanchard A
通讯作者：
Blanchard A
影响因子：
56.9
作者：
FRASER, CM;GOCAYNE, JD;VENTER, JC
通讯作者：
VENTER, JC
DOI：
10.1016/j.bbrc.2014.03.039
发表时间：
2014-04-18
影响因子：
3.1
作者：
Ku, Chuan;Lo, Wen-Sui;Kuo, Chih-Horng
通讯作者：
Kuo, Chih-Horng
影响因子：
4.8
作者：
Lee, JE;Cornell, KA;Howell, PL
通讯作者：
Howell, PL