An alternative way to initiate Notch1 signaling in non-small cell lung cancer.

An alternative way to initiate Notch1 signaling in non-small cell lung cancer.
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DOI:
10.3978/j.issn.2218-6751.2013.12.06
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发表时间:
2014-06
影响因子:
4
通讯作者:
Yi-lin Yang;D. Jablons;L. You
Yi-lin Yang;D. Jablons;L. You
中科院分区:
医学3区
文献类型:
--
作者:
Yi-lin Yang;D. Jablons;L. You

文献摘要

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非小细胞肺癌 (NSCLC) 细胞激活 Notch1 信号传导以促进细胞增殖并促进其生存。现在发现内皮 Delta 样配体 4 (Dll4) 可能介导 Notch1 激活并抑制肿瘤细胞生长。
Non-small cell lung cancer (NSCLC) cells activate Notch1 signaling to promote cell proliferation and facilitate their survival. It now emerges that endothelial Delta-like ligand 4 (Dll4) may mediate Notch1 activation and inhibit tumor cell growth.