Baclofen in the treatment of alcohol withdrawal syndrome: A comparative study vs diazepam
Baclofen in the treatment of alcohol withdrawal syndrome: A comparative study vs diazepam
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DOI：
10.1016/j.amjmed.2005.08.042
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发表时间：
2006-03-01
影响因子：
5.9
通讯作者：
Gasbarrini, G
中科院分区：
文献类型：
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作者：
Addolorato, G;Leggio, L;Gasbarrini, G
目的：苯二氮卓类药物是治疗酒精戒断综合征（AWS）的首选药物。最近的数据表明，巴氯芬可以减轻 AWS 症状。目前，尚无巴氯芬与 AWS 治疗中使用的任何苯二氮卓类药物之间的比较研究。因此，本研究旨在比较巴氯芬与地西泮治疗 AWS 的疗效、耐受性和安全性。 对象和方法：37 名 AWS 患者参加了该研究，并随机分为 2 组。 18 名患者（15 名男性，3 名女性；中位年龄：46.5 岁）口服巴氯芬（30 mg/天，连续 10 天）。 19 名患者（17 名男性，2 名女性；中位年龄：42.0 岁）口服地西泮（0.5-0.75 mg/kg/天，连续 6 天，从第 7 天到第 10 天每天逐渐减少剂量 25%）。临床研究所戒断评估（CIWA-Ar）用于评估AWS的身体症状。结果：巴氯芬和地西泮均显着降低了CIWA-Ar评分，两种治疗之间没有显着差异。当单独评估出汗、震颤、焦虑和躁动的 CIWA-Ar 分量表时，巴氯芬和地西泮治疗导致出汗、震颤和焦虑评分显着下降，两种药物治疗之间没有显着差异。两种治疗均降低了躁动评分，尽管地西泮比巴氯芬稍微快一些。结论：巴氯芬治疗无并发症 AWS 的疗效与“金标准”地西泮相当。这些结果表明巴氯芬可被视为治疗无并发症 AWS 的新药。 (c) 2006 Elsevier Inc. 保留所有权利。
PURPOSE: Benzodiazepines are the drugs of choice in the treatment of alcohol withdrawal syndrome (AWS). Recent data have shown that baclofen may reduce AWS symptoms. At present, no comparative studies between baclofen and any benzodiazepine used in AWS treatment are available. Accordingly, the present study was designed to compare efficacy, tolerability and safety of baclofen versus diazepam in the treatment of AWS.SUBJECTS AND METHODS: Thirty-seven patients with AWS were enrolled in the study and randomly divided into 2 groups. Baclofen (30 mg/day for 10 consecutive days) was orally administered to 18 patients (15 males, 3 females; median age: 46.5 years). Diazepam (0.5- 0.75 mg/kg/day for 6 consecutive days, tapering the dose by 25% daily from day 7 to day 10) was orally administered to 19 patients (17 men, 2 women; median age: 42.0 years). The Clinical Institute Withdrawal Assessment (CIWA-Ar) was used to evaluate physical symptoms of AWS.RESULTS: Both baclofen and diazepam significantly decreased CIWA-Ar score, without significant differences between the 2 treatments. When CIWA-Ar subscales for sweating, tremors, anxiety and agitation were evaluated singly, treatment with baclofen and diazepam resulted in a significant decrease in sweating, tremors and anxiety score, without significant differences between the 2 drug treatments. Both treatments decreased the agitation score, although diazepam was slightly more rapid than baclofen.CONCLUSION: The efficacy of baclofen in treatment of uncomplicated AWS is comparable to that of the '' gold standard '' diazepam. These results suggest that baclofen may be considered as a new drug for treatment of uncomplicated AWS. (c) 2006 Elsevier Inc. All rights reserved.