Comparison of trends in tuberculosis incidence among adults living with HIV and adults without HIV--Kenya, 1998-2012.
Comparison of trends in tuberculosis incidence among adults living with HIV and adults without HIV--Kenya, 1998-2012.
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DOI：
10.1371/journal.pone.0099880
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
De Cock KM
中科院分区：
文献类型：
--
作者：
Yuen CM;Weyenga HO;Kim AA;Malika T;Muttai H;Katana A;Nganga L;Cain KP;De Cock KM
在肯尼亚，没有说明感染和未感染艾滋病毒者之间结核病发病率的比较，公共卫生干预措施对这两个群体结核病发病率的不同影响也不清楚。我们估计了2006-2012年期间按艾滋病毒状态分层的结核病年发病率，其依据是报告的结核病患者（有和无艾滋病毒感染）人数、一般人群中艾滋病毒感染的患病率以及总人口。我们还粗略估计了1998-2012年期间按艾滋病毒状态分层的结核病年发病率，假设结核病患者与普通人群的艾滋病毒流行率比率恒定。1998-2004年期间，感染艾滋病毒和未感染艾滋病毒的成年人中结核病发病率均有所上升，但在2007年之前保持相对稳定。在2007-2012年期间，结核病发病率在感染艾滋病毒的成年人中下降了28-44%，在未感染艾滋病毒的成年人中下降了11-26%，同时抗逆转录病毒疗法的使用增加。2012年，感染艾滋病毒的成年人的结核病发病率（每100 000人中有1 839 - 1 936例）仍然是未感染艾滋病毒的成年人（每100 000人中有231-238例）的八倍，大约三分之一的结核病病例可归因于艾滋病毒。虽然感染和未感染艾滋病毒的成年人的结核病发病率有所下降，但感染艾滋病毒的人中结核病发病率居高不下以及这两个群体之间的差距令人关切。要解决这些问题，就必须及早诊断艾滋病毒，及早开始抗逆转录病毒治疗，定期筛查结核病，对艾滋病毒感染者进行异烟肼预防性治疗，并在一般人群中控制结核病。
In Kenya, the comparative incidences of tuberculosis among persons with and without HIV have not been described, and the differential impact of public health interventions on tuberculosis incidence in the two groups is unknown. We estimated annual tuberculosis incidence stratified by HIV status during 2006–2012 based on the numbers of reported tuberculosis patients with and without HIV infection, the prevalence of HIV infection in the general population, and the total population. We also made crude estimates of annual tuberculosis incidence stratified by HIV status during 1998–2012 by assuming a constant ratio of HIV prevalence among tuberculosis patients compared to the general population. Tuberculosis incidence among both adults with HIV and adults without HIV increased during 1998–2004 then remained relatively stable until 2007. During 2007–2012, tuberculosis incidence declined by 28–44% among adults with HIV and by 11–26% among adults without HIV, concurrent with an increase in antiretroviral therapy uptake. In 2012, tuberculosis incidence among adults with HIV (1,839–1,936 cases/100,000 population) was still eight times as high as among adults without HIV (231–238 cases/100,000 population), and approximately one third of tuberculosis cases were attributable to HIV. Although tuberculosis incidence has declined among adults with and without HIV, the persistent high incidence of tuberculosis among those with HIV and the disparity between the two groups are concerning. Early diagnosis of HIV, early initiation of antiretroviral therapy, regular screening for tuberculosis, and isoniazid preventive therapy among persons with HIV, as well as tuberculosis control in the general population, are required to address these issues.
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DOI：
10.1073/pnas.1005660107
发表时间：
2010-11-09
影响因子：
11.1
作者：
Williams, Brian G.;Granich, Reuben;Dye, Christopher
通讯作者：
Dye, Christopher
影响因子：
168.9
作者：
Samandari, Taraz;Agizew, Tefera B.;Wells, Charles D.
通讯作者：
Wells, Charles D.
DOI：
10.1016/0962-8479(95)90572-3
发表时间：
1995-02-01
期刊：
TUBERCLE AND LUNG DISEASE
影响因子：
--
作者：
RICHARDS, SB;STLOUIS, ME;DECOCK, KM
通讯作者：
DECOCK, KM
影响因子：
3.8
作者：
Pretorius, Carel;Menzies, Nicolas A.;Dodd, Peter J.
通讯作者：
Dodd, Peter J.
影响因子：
3
作者：
Obermeyer CM;Bott S;Bayer R;Desclaux A;Baggaley R;MATCH Study Group
通讯作者：
MATCH Study Group