Development of antimicrobial-loaded polyurethane films for drug-eluting catheters
Development of antimicrobial-loaded polyurethane films for drug-eluting catheters
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DOI：
10.1002/app.46467
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发表时间：
2018-07-15
影响因子：
3
通讯作者：
Auad, Maria L.
中科院分区：
文献类型：
--
作者：
Barde, Mehul;Davis, Montoia;Auad, Maria L.
To prepare antibacterial, polymeric catheters for preventing catheter-induced infections, sulfathiazole was loaded into polyurethane by solubilizing with solvents and the resultant films were cast. Fourier transform infrared spectroscopy confirmed the presence of sulfathiazole in the drug-loaded polyurethane films. The thermal and mechanical properties of the films were assessed using differential scanning calorimetry and dynamic mechanical analysis. The drug-loaded films were immersed in constantly stirred, deionized water at 37 degrees C for in vitro drug release study. The experimental data obtained from the in vitro drug release study were fit into mathematical models. Antibacterial efficiency of released sulfathiazole was evaluated by Escherichia coli growth inhibition test. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46467.
