Mitochondrial quality orchestrates muscle-adipose dialog to alleviate dietary obesity.
Mitochondrial quality orchestrates muscle-adipose dialog to alleviate dietary obesity.
复制标题
线粒体质量协调肌肉与脂肪的对话，以减轻饮食肥胖。
DOI：
10.1016/j.phrs.2018.12.020
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发表时间：
2019
影响因子：
9.3
通讯作者：
Gan Zhenji
中科院分区：
文献类型：
--
作者：
Xu Zhisheng;Fu Tingting;Guo Qiqi;Sun Wanping;Gan Zhenji
骨骼肌健康对人类健康和疾病至关重要，并由燃烧燃料，线粒体ATP生产和收缩的能力决定。骨骼肌中的高质量线粒体对于维持能量稳态以响应无数生理或病理生理应激是必不可少的。一个复杂的线粒体质量控制系统，包括线粒体自噬，动力学，和蛋白质水解已被确定，这保持其功能的完整性。在这篇综述中，我们讨论了最近的研究强调线粒体质量控制机制，管理全身代谢骨骼肌。越来越多的证据表明，线粒体可以与细胞核“交流”，并在应激反应期间触发适应性基因组重编程。我们专注于参与线粒体质量控制系统的线粒体通信，驱动肌肉脂肪对话的调节，并建议，肌肉特异性调节线粒体质量影响系统的稳态。
Skeletal muscle fitness is vital for human health and disease and is determined by the capacity for burning fuel, mitochondrial ATP production, and contraction. High quality mitochondria in skeletal muscle are essential for maintaining energy homeostasis in response to a myriad of physiologic or pathophysiological stresses. A sophisticated mitochondrial quality control system including mitochondrial autophagy, dynamics, and proteolysis has been identified, which maintains their functional integrity. In this review, we discuss recent studies highlighting mitochondrial quality control mechanisms that govern systemic metabolism by skeletal muscles. Increasing evidence suggests that mitochondria can “communicate” with the nucleus and triggers adaptive genomic re-programming during stress response. We focus on participation of the mitochondrial quality control system in the regulation of mitochondrial communications that drive the muscle to adipose dialog and suggest that muscle-specific regulation of mitochondrial quality impacts systemic homeostasis.