Glucagon treatment stimulates the metabolism of hepatic submitochondrial particles.
Glucagon treatment stimulates the metabolism of hepatic submitochondrial particles.
复制标题
胰高血糖素治疗刺激肝软骨下颗粒的新陈代谢。
DOI：
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发表时间：
1978
影响因子：
4.8
通讯作者：
R. Haynes
中科院分区：
文献类型：
--
作者：
M. Titheradge;S. B. Binder;Russell K Yamazaki;R. Haynes
Hepatic submitochondrial particles, prepared at neutral pH from rats pretreated with glucagon, exhibited stimulated rates of State 3 and uncoupled respiration when succinate or NADH were the substrates, but not when ascorbate plus N,N,N',N'-tetramethyl-p-phenylenediamine were employed. Measurements of 8-anilino-1-naphthalenesulfonic acid fluorescence in the particles indicated that glucagon treatment resulted in a stimulation of energization supported by succinate respiration or ATP hydrolysis. Similarly, the energy-linked pyridine nucleotide transhydrogenase and reverse electron flow reactions driven by succinate oxidation or ATP were also stimulated. The results indicate that mitochondrial substrate transport is not the prime locus of glucagon action. It is suggested that the increased level of energization in particles prepared from glucagon-treated rats is a reflection of a stimulation of the respiratory chain, possibly between cytochromes b and c, and the ATP-forming reactions.
