Mechanisms of neural response to gastrointestinal nutritive stimuli: the gut-brain axis.
Mechanisms of neural response to gastrointestinal nutritive stimuli: the gut-brain axis.
复制标题
对胃肠营养刺激的神经反应机制：肠脑轴。
DOI：
10.1053/j.gastro.2009.02.057
复制
发表时间：
2009
期刊：
影响因子：
29.4
通讯作者：
K. Torii
中科院分区：
文献类型：
--
作者：
T. Tsurugizawa;A. Uematsu;E. Nakamura;M. Hasumura;M. Hirota;T. Kondoh;H. Uneyama;K. Torii
背景与目标
肠-脑轴将营养信息从胃肠道传递到大脑，对于膳食营养素的检测非常重要。我们使用大鼠前脑的功能性磁共振成像来研究该途径如何将营养信息从胃肠道传递到大脑。
方法
我们通过比较24只对照组大鼠和22只接受迷走神经切断术的大鼠之间血氧水平依赖性信号的变化来研究迷走神经的贡献。在α-氯醛糖麻醉下连续收集L-谷氨酸或葡萄糖胃内输注开始前30分钟和开始后60分钟的功能数据。测量血浆胰岛素、L-谷氨酸和血糖水平，并与血氧水平依赖性信号进行比较。
结果
灌胃给予L-谷氨酸或葡萄糖在不同的前脑区域，包括皮层，下丘脑和边缘区，在不同的时间点诱导激活。迷走神经切断术强烈抑制前脑大部分区域中L-谷氨酸诱导的激活。与此相反，迷走神经切断术并没有显着影响大脑激活诱导的葡萄糖。相反，脑桥核和杏仁核中的血氧水平依赖性信号，响应于胃肠道葡萄糖，随着血浆胰岛素水平的波动而沿着变化。
结论
这些结果表明，迷走神经和胰岛素是重要的信号胃肠道营养物质的存在，大鼠前脑。这些信号通路依赖于摄入的营养素。
BACKGROUND & AIMS
The gut-brain axis, which transmits nutrient information from the gastrointestinal tract to the brain, is important for the detection of dietary nutrients. We used functional magnetic resonance imaging of the rat forebrain to investigate how this pathway conveys nutrient information from the gastrointestinal tract to the brain.
METHODS
We investigated the contribution of the vagus nerve by comparing changes of blood oxygenation level-dependent signals between 24 control rats and 22 rats that had undergone subdiaphragmatic vagotomy. Functional data were collected under alpha-chloralose anesthesia continuously 30 minutes before and 60 minutes after the start of intragastric infusion of L-glutamate or glucose. Plasma insulin, L-glutamate, and blood glucose levels were measured and compared with blood oxygenation level-dependent signals.
RESULTS
Intragastric administration of L-glutamate or glucose induced activation in distinct forebrain regions, including the cortex, hypothalamus, and limbic areas, at different time points. Vagotomy strongly suppressed L-glutamate-induced activation in most parts of the forebrain. In contrast, vagotomy did not significantly affect brain activation induced by glucose. Instead, blood oxygenation level-dependent signals in the nucleus accumbens and amygdala, in response to gastrointestinal glucose, varied along with fluctuations of plasma insulin levels.
CONCLUSIONS
These results indicate that the vagus nerve and insulin are important for signaling the presence of gastrointestinal nutrients to the rat forebrain. These signal pathways depend on the ingested nutrients.
大剂量口服谷氨酸钠对禁食男性受试者的短期神经内分泌影响。
DOI：
10.1210/jcem.81.1.8550750
发表时间：
1996
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Fernstrom,JD;Cameron,JL;Fernstrom,MH;McConaha,C;Weltzin,TE;Kaye,WH
通讯作者：
Kaye,WH