The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
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DOI：
10.1038/90992
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发表时间：
2001-08-01
期刊：
影响因子：
82.9
通讯作者：
Scherer, PE
中科院分区：
文献类型：
--
作者：
Berg, AH;Combs, TP;Scherer, PE
Acrp 30是在脂肪组织中合成的循环蛋白。在小鼠中单次注射纯化的重组Acrp 30导致循环Acrp 30水平升高2-3倍，这引发基础葡萄糖水平的短暂降低。在ob/ob、NOD（非肥胖型糖尿病）或链脲霉素处理的小鼠中的类似处理短暂消除高血糖症。这种对葡萄糖的影响与胰岛素水平的增加无关。此外，在分离的肝细胞中，Acrp 30增加亚生理水平的胰岛素抑制葡萄糖产生的能力。因此，我们认为Acrp 30是一种有效的胰岛素增强剂，可将脂肪组织和全身葡萄糖代谢联系起来。
Acrp30 is a circulating protein synthesized in adipose tissue. A single injection in mice of purified recombinant Acrp30 leads to a 2-3-fold elevation in circulating Acrp30 levels, which triggers a transient decrease in basal glucose levels. Similar treatment in ob/ob, NOD (non-obese diabetic) or streptozotocin-treated mice transiently abolishes hyperglycemia. This effect on glucose is not associated with an increase in insulin levels. Moreover, in isolated hepatocytes, Acrp30 increases the ability of sub-physiological levels of insulin to suppress glucose production. We thus propose that Acrp30 is a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism.