ALCOHOL, MARIJUANA, AND TOBACCO - EFFECTS OF PRENATAL EXPOSURE ON OFFSPRING GROWTH AND MORPHOLOGY AT AGE-6
ALCOHOL, MARIJUANA, AND TOBACCO - EFFECTS OF PRENATAL EXPOSURE ON OFFSPRING GROWTH AND MORPHOLOGY AT AGE-6
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DOI：
10.1111/j.1530-0277.1994.tb00041.x
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发表时间：
1994-08-01
影响因子：
3.2
通讯作者：
ROBLES, N
中科院分区：
文献类型：
--
作者：
DAY, NL;RICHARDSON, GA;ROBLES, N
人们对产前接触酒精的长期影响知之甚少。关于怀孕期间接触大麻或烟草的纵向影响的报告甚至更少。这项研究对参加孕产妇健康实践和儿童发展项目的 668 名儿童进行了为期 6 年的随访。母亲在怀孕第 4 和 7 个月时接受采访，母亲和儿童在分娩时、8 个月和 18 个月以及产后 3 和 6 年时接受评估。 6岁时，产前接触酒精的儿童体重、身高、头围和睑裂宽度均明显偏小。这些对父亲的影响是由产前酒精暴露对 8 个月时的后代的影响介导的。产前酒精暴露也与母亲报告的孩子 6 岁时的食欲显着相关。产前接触大麻或烟草对孩子 6 岁时的生长没有影响。产前接触酒精、大麻或烟草与形态异常率（包括胎儿酒精综合征的特征）之间也没有显着关系。
Little is known about the long-term effects of prenatal exposure to alcohol. There are even fewer reports on the longitudinal effects of exposure to either marijuana or tobacco during pregnancy. This study is on the 6-year follow-up of 668 children enrolled in the Maternal Health Practices and Child Development Project. Mothers were interviewed at the 4th and 7th months of pregnancy, and mothers and children were evaluated at delivery, 8, and 18 months, and 3 and 6 years postpartum. At 6 years of age, children who were exposed to alcohol prenatally were significantly smaller in weight, height, head circumference, and palpebral fissure width. These effects on sire were mediated by the effect of prenatal alcohol exposure on the offspring at 8 months. Prenatal alcohol exposure was also significantly associated with maternal reports of the child's appetite at 6 years. There were no effects of prenatal marijuana or tobacco exposure on growth when the children were age 6. There were also no significant relationships between prenatal exposure to alcohol, marijuana, or tobacco and the rate of morphologic anomalies, including the features of the fetal alcohol syndrome.