Palliative care for patients with locally advanced and metastatic non-small cell lung cancer.
Palliative care for patients with locally advanced and metastatic non-small cell lung cancer.
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局部晚期和转移性非小细胞肺癌患者的姑息治疗。
DOI：
10.3978/j.issn.2224-5820.2013.08.02
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发表时间：
2013
影响因子：
--
通讯作者：
Joshua Jones
中科院分区：
文献类型：
--
作者：
C. Simone;Joshua Jones
非小细胞肺癌（NSCLC）通常出现在晚期，并可能导致显著的症状负担。许多晚期NSCLC患者出现的症状包括疼痛、呼吸困难、咳嗽、食欲下降、体重减轻和抑郁。晚期或转移性NSCLC的早期姑息治疗可以减轻症状，改善生活质量，延长生存期。姑息治疗干预由一个跨学科的团队专注于病人和家庭，并解决身体症状，疾病的理解，应对，心理和精神困扰。在最佳支持治疗的基础上增加全身治疗可以进一步改善生活质量并延长生存期。胸部外照射放射治疗放射治疗耐受性良好，可以改善生活质量，缓解咯血、疼痛、咳嗽和呼吸困难等症状。对于中心气道阻塞，外照射治疗、支气管内近距离放射治疗、Nd：YAG激光治疗和光动力治疗可改善症状。症状性肺转移到脑、肾上腺和肝或压迫或撞击脊髓或神经根也可导致患者症状，并且可通过医学和药物干预、放射疗法、手术、消融疗法和全身疗法来管理。所有治疗晚期或转移性NSCLC患者的医疗保健提供者应优先考虑姑息治疗，在每次患者就诊时评估疼痛、呼吸困难、应对和心理社会困扰以及其他症状，以降低患者发病率，改善生活质量，并可能延长生存期。
Non-small cell lung cancer (NSCLC) often presents at an advanced stage and can result in a significant symptomatic burden. Many patients with advanced NSCLC experience symptoms that include pain, dyspnea, cough, decreased appetite, weight loss, and depression. Early initiation of palliative care for advanced or metastatic NSCLC can reduce symptoms, improve quality of life, and prolong survival. Palliative care interventions by an interdisciplinary team focus on patient and family and address physical symptoms, illness understanding, coping, and psychosocial and spiritual distress. The addition of systemic therapy to best supportive care can further improve quality of life and prolong survival. Thoracic external beam radiation therapy beam radiotherapy is well tolerated and can improve quality of life and relieve symptoms such as hemoptysis, pain, cough, and dyspnea. For central airway obstruction, external beam radiation therapy, endobronchial brachytherapy, Nd:YAG laser therapy, and photodynamic therapy can improve symptoms. Symptomatic lung metastases to the brain, adrenal glands, and liver or compressing or impinging the spinal cord or nerve roots can also result in patient symptoms and can be managed with medical and pharmacologic interventions, radiation therapy, surgery, ablative therapy, and systemic therapy. All healthcare providers treating patients with advanced or metastatic NSCLC should make palliative care a priority by assessing for pain, dyspnea, coping and psychosocial distress, and other symptoms at each patient encounter to reduce patient morbidity, improve quality of life, and potentially prolong survival.
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影响因子：
45.3
作者：
Movsas, Benjamin;Moughan, Jennifer;Bruner, Deborah Watkins
通讯作者：
Bruner, Deborah Watkins
影响因子：
51.1
作者：
Quinten, Chantal;Coens, Corneel;Bottomley, Andrew
通讯作者：
Bottomley, Andrew
DOI：
--
发表时间：
1998-05
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
P. Bunn;K. Kelly
通讯作者：
P. Bunn;K. Kelly
影响因子：
158.5
作者：
CLEELAND, CS;GONIN, R;PANDYA, KJ
通讯作者：
PANDYA, KJ