Catalase gene C‐262T polymorphism: Importance in ulcerative colitis
Catalase gene C‐262T polymorphism: Importance in ulcerative colitis
复制标题
过氧化氢酶基因 C-262T 多态性：在溃疡性结肠炎中的重要性
DOI：
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发表时间：
2013
影响因子：
4.1
通讯作者：
Saeideh Torabi Dalivandan
中科院分区：
文献类型：
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作者：
Siamak Khodayari;Z. Salehi;Saba Fakhrieh Asl;K. Aminian;Nadia Mirzaei Gisomi;Saeideh Torabi Dalivandan
活性氧（ROS）是细胞代谢的副产物，在细胞的正常生理中起着重要作用。然而，当ROS的产生超过抗氧化能力时，一种被称为氧化应激的状态，对细胞大分子的损害就会出现。过氧化氢酶在对抗活性氧中起着至关重要的作用。过氧化氢酶（CAT）启动子区域（C‐262T）的常见多态性改变了表达和血液过氧化氢酶水平，并导致许多人类疾病。溃疡性结肠炎（UC）是一种大肠炎症，已知受氧化应激影响。在这项研究中，我们旨在评估CAT C‐262T多态性与UC风险的关系。
Reactive oxygen species (ROS) are by‐products of the cellular metabolism and have important roles in the normal physiology of the cell. However, when ROS production exceeds the antioxidant capacity, a state known as oxidative stress, damage to cellular macromolecules emerges. A crucial role in counteracting ROS is played by the enzyme catalase. A common polymorphism in the catalase (CAT) promoter region (C‐262T) alters the expression as well as blood catalase levels, and leads to a number of human diseases. Ulcerative colitis (UC) is an inflammatory condition of the large bowel that is known to be influenced by oxidative stress. In this study, we aimed to evaluate the association of CAT C‐262T polymorphism on the risk of UC.