Diffusive dynamics of water in the presence of homologous disaccharides:: A comparative study by quasi elastic neutron scattering.: IV.
Diffusive dynamics of water in the presence of homologous disaccharides:: A comparative study by quasi elastic neutron scattering.: IV.
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DOI：
10.1021/jp002155z
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发表时间：
2001-03-08
影响因子：
3.3
通讯作者：
Telling, MTF
中科院分区：
文献类型：
--
作者：
Magazù, S;Villari, V;Telling, MTF
本文报道了双糖在水溶液中的动力学研究，并讨论了它们与水相互作用的作用，这似乎对生物膜和组织具有保护作用。特别是，使用 QENS（英国 RAL ISIS 的 IRIS），我们比较了三种同源二糖（海藻糖、麦芽糖和蔗糖）的准弹性光谱，每个二糖分子水合有 20 个水分子。同位素取代方法使我们能够研究二糖存在下水的动力学。我们的结果表明，海藻糖在减缓水动力学、诱导更广泛的水化层方面最有效。
The present paper reports on the study of the disaccharides' dynamics in aqueous solutions and discusses the role of their interaction with water, which seems to be responsible for the protective action on biological membranes and tissues. In particular, using QENS (IRIS at ISIS, RAL, U.K.) we compared the quasielastic spectra from three homologous disaccharides (trehalose, maltose, and sucrose) with a hydration of 20 water molecules per each disaccharide molecule. The isotopic substitution method allowed us to study also the dynamics of water in the presence of the disaccharides. Our results show that trehalose is the most effective in slowing down the water dynamics, inducing a more extensive hydration layer.