SDF-1 expression after preoperative chemoradiotherapy is associated with prognosis in patients with advanced lower rectal cancer.
SDF-1 expression after preoperative chemoradiotherapy is associated with prognosis in patients with advanced lower rectal cancer.
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DOI：
10.2152/jmi.68.309
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Shohei Okikawa;Jun Higashijima;M. Nishi;T. Yoshimoto;Shohei Eto;C. Takasu;H. Kashihara;T. Tokunaga;K. Yoshikawa;M. Shimada
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文献类型：
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作者：
Shohei Okikawa;Jun Higashijima;M. Nishi;T. Yoshimoto;Shohei Eto;C. Takasu;H. Kashihara;T. Tokunaga;K. Yoshikawa;M. Shimada
基质细胞衍生因子-1（SDF-1）表达与癌症进展相关，是预后的生物标志物。我们阐明了SDF-1表达对进展期低位直肠癌患者放化疗（CRT）抵抗和预后的意义。我们评估了98例术前接受CRT的晚期低位直肠癌患者。所有患者均接受40戈伊的放射治疗，同时接受含氟嘧啶类药物的化疗，然后进行手术切除。采用免疫组化法检测手术标本中SDF-1的表达。我们将患者分为SDF-1阳性组（n = 52）和SDF-1阴性组（n = 46），比较临床病理因素和生存率。SDF-1阳性组比SDF-1阴性组对CRT更具抵抗力（无应答率分别为63.5%和47.8%; p = 0.12）。SDF-1阳性组的总生存期（OS）显著低于SDF-1阴性组（5年OS分别为73.4%和88.0%; p = 0.02），无病生存期（DFS）更差（5年DFS分别为61.0%和74.1%; p = 0.07）。多变量分析证实，SDF-1表达是OS的显著独立预后预测因子（p = 0.04）。SDF-1在术前CRT后的表达与晚期低位直肠癌患者的不良预后显著相关，是一种有前途的生物标志物。J.医学投资68：309-314，2021年8月。
Stromal cell-derived factor-1 (SDF-1) expression is associated with cancer progression, as a biomarker of prognosis. We clarified the significance of SDF-1 expression on chemoradiotherapy (CRT) resistance and prognosis in advanced lower rectal cancer patients. We evaluated 98 patients with advanced lower rectal cancer who underwent preoperative CRT. All patients received 40 Gy of radiation therapy, with concurrent chemotherapy containing fluorinated pyrimidines, followed by surgical resection. SDF-1 expression in surgical specimens was examined by immunohistochemistry. We divided the patients into SDF-1-positive- (n = 52) and SDF-1-negative groups (n = 46) and compared the clinicopathological factors and survival rates. The SDF-1-positive group was more resistant to CRT than the SDF-1-negative group (non-responder rate, 63.5% vs. 47.8%, respectively ; p = 0.12). Overall survival (OS) in the SDF-1 positive group was significantly poorer vs. the SDF-1-negative group (5-year OS, 73.4% vs. 88.0%, respectively ; p = 0.02), and disease-free survival (DFS) was worse (5-year DFS, 61.0% vs. 74.1%, respectively ; p = 0.07). Multivariate analysis confirmed that SDF-1 expression was a significant independent prognostic predictor of OS (p = 0.04). SDF-1 expression after preoperative CRT is significantly associated with a poor prognosis in advanced lower rectal cancer patients and is a promising biomarker. J. Med. Invest. 68 : 309-314, August, 2021.