A HYPOTHESIS - NONSTEROIDAL ANTIINFLAMMATORY DRUGS REDUCE THE INCIDENCE OF LARGE-BOWEL CANCER
A HYPOTHESIS - NONSTEROIDAL ANTIINFLAMMATORY DRUGS REDUCE THE INCIDENCE OF LARGE-BOWEL CANCER
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DOI：
10.1093/jnci/83.5.355
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发表时间：
1991-03-06
期刊：
影响因子：
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通讯作者：
SHAPIRO, S
中科院分区：
文献类型：
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作者：
ROSENBERG, L;PALMER, JR;SHAPIRO, S
非甾体抗炎药（NSAID）抑制前列腺素合成和肿瘤生长在啮齿动物结肠。 我们在一项以医院为基础的病例对照研究中评估了NSAID的使用与人类大肠癌风险的关系，该研究包括1326例结直肠癌患者和4891例对照患者。对于持续到访谈前一年的常规NSAID使用，多变量相对风险估计值为0.5（95%置信区间，0.4至0.8）;估计值随着使用时间的增加而降低，但趋势无统计学意义。无论使用癌症还是非癌症对照，都获得了类似的结果，并且在男性和女性以及年龄小于和大于60岁的受试者中，结肠癌和直肠癌的负相关性都很明显。 至少1年前停用的常规NSAID使用和非常规使用与风险无关。 几乎所有常规NSAID使用的药物都是含阿司匹林的药物。目前的数据表明，持续使用非甾体类抗炎药可降低人类大肠癌的发病率。
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit prostaglandin synthesis and tumor growth in the rodent colon. We assessed NSAID use in relation to risk of human large-bowel cancer in a hospital-based, case-control study of 1326 patients with colorectal cancer and 4891 control patients. For regular NSAID use that continued into the year before interview, the multivariate relative risk estimate was 0.5 (95% confidence interval, 0.4 to 0.8); the estimate decreased as the duration of use increased, but the trend was not statistically significant. Similar results were obtained whether cancer or non-cancer controls were used, and the inverse association was apparent for both colon cancer and rectal cancer in men and women and in subjects younger and older than 60 years. Regular NSAID use that had been discontinued at least 1 year previously and non-regular use were not associated with risk. Almost all regular NSAID use was of aspirin-containing drugs. The present data suggest that the sustained use of NSAIDs reduces the incidence of human large-bowel cancer.