Bacteria and viruses induce production of interferon in the cerebrospinal fluid of children with acute meningitis: a study of 57 cases and review.
Bacteria and viruses induce production of interferon in the cerebrospinal fluid of children with acute meningitis: a study of 57 cases and review.
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细菌和病毒诱导急性脑膜炎儿童脑脊液中干扰素的产生：57例病例的研究和综述。
DOI：
10.1093/clinids/13.6.1061
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
S. Baron
中科院分区：
文献类型：
--
作者：
T. Chonmaitree;S. Baron
分析了57例细菌性或肠病毒性脑膜炎的婴儿和儿童的脑脊液中是否存在干扰素（IFN）。诊断为脑膜炎时采集脑脊液；所有病例均分离出细菌或肠道病毒。在24%的细菌性脑膜炎病例和75%的病毒性脑膜炎病例的脑脊液中检测到IFN。细菌性脑膜炎患者IFN滴度一般较低。无论是IFN的存在还是IFN滴度水平都与患者的年龄或CSF中白细胞或单个核细胞的数量无关。柯萨奇病毒诱导干扰素的产生比埃可病毒更一致且滴度更高。35例对照患者脑脊液中均未检测到IFN。文献回顾和我们的数据表明，脑脊液中IFN的存在提示中枢神经系统感染，但不能区分细菌感染和病毒感染。细菌性脑膜炎患儿脑脊液中IFN的发现支持了细菌和其他非病毒性微生物诱导IFN产生的证据。干扰素在非病毒性感染中的保护作用值得进一步研究。
The CSF of 57 infants and children with bacterial or enterovirus meningitis was analyzed for the presence of interferon (IFN). CSF was collected when the diagnosis of meningitis was made; a bacterium or enterovirus was isolated in all cases. IFN was detectable in CSF in 24% of cases of bacterial meningitis and in 75% of cases of viral meningitis. Titers of IFN were generally lower in cases of bacterial meningitis. Neither the presence of IFN nor the level of IFN titers correlated with the patient's age or number of white blood cells or mononuclear cells in the CSF. Coxsackievirus induced production of IFN more consistently and in higher titers than did echovirus. None of 35 control patients had detectable IFN in CSF. A literature review and our data indicate that the presence of IFN in CSF suggests infection of the CNS but does not differentiate bacterial from viral infection. The finding of IFN in the CSF of children with bacterial meningitis supports evidence that bacteria and other nonviral microorganisms induce IFN production. The protective role of IFN in nonviral infections deserves further investigation.