Lung function and glucose metabolism: An analysis of data from the Third National Health and Nutrition Examination Survey
Lung function and glucose metabolism: An analysis of data from the Third National Health and Nutrition Examination Survey
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DOI：
10.1093/aje/kwi076
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发表时间：
2005-03-15
影响因子：
5
通讯作者：
Fogarty, A
中科院分区：
文献类型：
--
作者：
McKeever, TM;Weston, PJ;Fogarty, A
尽管糖尿病患者的肺功能下降，但非糖尿病患者的血糖控制措施与肺功能之间的剂量反应关系尚不清楚。作者使用第三次全国健康和营养检查调查（1988-1994）的数据来研究没有糖尿病临床诊断的成年人群中葡萄糖耐量测试反应与其他葡萄糖稳态和肺功能测量之间的关系。口服 75 g 葡萄糖后 2 小时的血浆葡萄糖水平与 1 秒用力呼气量 (FEV1) 呈负相关，挑战后血糖最高五分位数的人与最低五分位数的人相比，差异为 -144.7 ml（95% 置信区间：-231.9，-57.4）。其他葡萄糖自动调节指标也与 FEV1 存在类似的负相关关系。肺功能似乎与空腹血糖水平无关。用力肺活量 (FVC) 也存在类似的关联，但 FEV1:FVC 比率则不然。在整个研究人群中，既往诊断为糖尿病的患者的 FEV1 为 119.1 ml（95% 置信区间：-161.5，-76.6），低于未患糖尿病的患者。对于糖尿病控制不佳的人来说，这种影响更大。这些发现表明，葡萄糖自动调节受损与肺功能受损有关。
Although people with diabetes have decreased lung function, the dose-response relation between measures of glucose control and lung function in nondiabetic people is not known. The authors used data from the Third National Health and Nutrition Examination Survey (1988-1994) to investigate the relation between glucose tolerance test response and other measures of glucose homeostasis and lung function in an adult population without a clinical diagnosis of diabetes. Plasma glucose level 2 hours after oral administration of 75 g of glucose was inversely related to forced expiratory volume in 1 second (FEV1), with a difference of -144.7 ml (95% confidence interval: -231.9, -57.4) for persons in the highest quintile of postchallenge glucose compared with the lowest. Similar inverse associations with FEV1 were found for other measures of glucose autoregulation. Lung function did not appear to be related to fasting glucose level. Similar associations were seen for forced vital capacity (FVC) but not for the FEV1:FVC ratio. In the total study population, persons with previously diagnosed diabetes had an FEV1 119.1 ml (95% confidence interval: -161.5, -76.6) lower than persons without diabetes. This effect was greater in those with poorly controlled diabetes. These findings suggest that impaired glucose autoregulation is associated with impaired lung function.