Elevated gene expression of S100A12 is correlated with the predominant clinical inflammatory factors in patients with bacterial pneumonia
Elevated gene expression of S100A12 is correlated with the predominant clinical inflammatory factors in patients with bacterial pneumonia
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DOI：
10.3892/mmr.2015.3295
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发表时间：
2015-06-01
影响因子：
3.4
通讯作者：
Luo, Cheng
中科院分区：
文献类型：
--
作者：
Hou, Fei;Wang, Likui;Luo, Cheng
Inflammation is the predominant characteristic of pneumonia. The present study aimed to to identify a faster and more reliable novel inflammatory marker for the diagnosis of pneumonia. The expression of the S100A12 gene was analyzed by reverse transcription quantitative polymerase chain reaction in samples obtained from 46 patients with bacterial pneumonia and other infections, compared with samples from 20 healthy individuals, using the 2(-Delta Delta Ct) method. The expression levels of S100A12 were increased in 12 patients with bacterial pneumonia. Compared with clinical inflammatory data, a positive correlation was observed between the expression of the S100A12 gene and levels of white blood cells, C-reactive protein (CRP), thrombocytocrit, neutrophils, erythrocyte sedimentation and soterocytes, and an inverse correlation was observed with the width of red blood cell volume distribution and platelet distribution, monocytes and hemoglobin, using Pearson's product-moment correlation method. The P-value of CRP and erythrocyte sedimentation were revealed to be statistically significant (P1.0) determined using the 2(-Delta Delta Ct) method was associated with more severe respiratory diseases in the patients compromised by bacterial pneumonia, sepsis and pancreatitis. These findings suggested that S100Al2 is an effective marker for inflammatory diseases.
