New insights emerge as antibody repertoire diversification meets chromosome conformation.
New insights emerge as antibody repertoire diversification meets chromosome conformation.
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DOI：
10.12688/f1000research.17358.1
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Feeney, Ann J
中科院分区：
文献类型：
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作者：
Kenter, Amy L;Feeney, Ann J
在发育中的淋巴细胞中产生了大量独特的抗原受体。抗原受体基因座包含许多可变（V）、多样性（D）和连接（J）基因片段，其在非常大的基因组扩展区中排列并连接以形成可变区外显子。这个过程创造了生物体对大量不同病原体做出反应的可能性。在这里，我们认为潜在的分子机制，有利于一些V基因重组之前选择的最终抗原受体库。我们讨论了染色质结构，形成在抗原受体基因座，以允许空间接近之间的V，D和J基因片段，以及这些如何与抗原受体的多样性的产生。
Vast repertoires of unique antigen receptors are created in developing lymphocytes. The antigen receptor loci contain many variable (V), diversity (D), and joining (J) gene segments that are arrayed across very large genomic expanses and are joined to form variable-region exons. This process creates the potential for an organism to respond to large numbers of different pathogens. Here, we consider the underlying molecular mechanisms that favor some V genes for recombination prior to selection of the final antigen receptor repertoire. We discuss chromatin structures that form in antigen receptor loci to permit spatial proximity among the V, D, and J gene segments and how these relate to the generation of antigen receptor diversity.