Use of 19F magnetic resonance imaging to measure local cerebral blood volume.
Use of 19F magnetic resonance imaging to measure local cerebral blood volume.
复制标题
利用19F磁共振成像测量局部脑血容量。
DOI：
10.1002/mrm.1910290205
复制
发表时间：
1993
影响因子：
3.3
通讯作者：
Sloviter,HA
中科院分区：
文献类型：
--
作者：
Lu,D;Joseph,PM;Greenberg,JH;Lin,R;Mukherji,B;Sloviter,HA
局部脑血容量(LCBV)是脑血管生理学的重要功能参数，其定义为血液在脑组织中所占的比例。在大多数哺乳动物中，LCBV的分布是不均匀的，在正常二氧化碳条件下，LCBV的分布在2%到4%之间。LCBV受动脉二氧化碳分压(P，CO_2)的影响，在P，CO_2值的大范围内呈线性变化。已经开发了许多技术来使用正电子发射断层扫描(PET)(1，2)、单光子发射计算机断层扫描(SPECT)(3，4)、动态计算机断层扫描(5，6)和动态磁共振成像(MRI)(7，8)来获得人类和动物的LCBV图像。PET和SPECT是定量技术，但空间分辨率较低(约为
Local cerebral blood volume (LCBV), defined as the fraction of brain tissue volume that is composed of blood, is an important functional parameter of cerebrovascular physiology. The distribution of LCBV is heterogeneous and varies between 2% and 4% in most mammals under normocapnic conditions. LCBV is affected by the arterial carbon dioxide partial pressure (P, CO,), varying linearly over large range of P, CO, values. Numerous techniques have been developed to obtain LCBV images in humans and animals using positron emission tomography (PET)(1, 2), single photon emission computed tomography (SPECT)(3, 4), dynamic computed tomography (5, 6), and dynamic magnetic resonance imaging (MRI)(7, 8). PET and SPECT are quantitative techniques but have low spatial resolution (about zyxwvutsrqpon