The Nanotheranostic Researcher's Guide for Use of Animal Models of Traumatic Brain Injury.
The Nanotheranostic Researcher's Guide for Use of Animal Models of Traumatic Brain Injury.
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DOI：
10.3390/jnt2040014
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发表时间：
2021-12
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目前，创伤性脑损伤（TBI）是世界范围内损伤相关发病率和死亡率的主要原因，据估计，全球每年造成的损失达4000亿美元。与TBI相关的临床和临床前行为结果在本质上是异质性的，并受到损伤机制和频率的影响。以前的文献通过动物模型和行为任务的发展来研究这种关系。然而，这些方法的最新进展可能为将治疗方法转化为临床环境提供见解。在这篇综述中，我们描述了各种动物模型和行为任务，为评估TBI治疗方案的治疗效果提供指导。我们简要回顾了用于TBI分类的系统，并与已开发的动物模型进行了比较。此外，我们还讨论了行为任务在评估与TBI相关的结果中的作用。我们的目标是为纳米治疗领域的研究人员提供一个选择合适的创伤性脑损伤动物模型和评估结果的行为任务的指南，以促进该领域的研究。
Traumatic brain injury (TBI) is currently the leading cause of injury-related morbidity and mortality worldwide, with an estimated global cost of USD 400 billion annually. Both clinical and preclinical behavioral outcomes associated with TBI are heterogeneous in nature and influenced by the mechanism and frequency of injury. Previous literature has investigated this relationship through the development of animal models and behavioral tasks. However, recent advancements in these methods may provide insight into the translation of therapeutics into a clinical setting. In this review, we characterize various animal models and behavioral tasks to provide guidelines for evaluating the therapeutic efficacy of treatment options in TBI. We provide a brief review into the systems utilized in TBI classification and provide comparisons to the animal models that have been developed. In addition, we discuss the role of behavioral tasks in evaluating outcomes associated with TBI. Our goal is to provide those in the nanotheranostic field a guide for selecting an adequate TBI animal model and behavioral task for assessment of outcomes to increase research in this field.