Regional cerebral glucose utilization in rats with portacaval anastomosis.
Regional cerebral glucose utilization in rats with portacaval anastomosis.
复制标题
门静脉吻合大鼠的局部脑葡萄糖利用。
DOI：
10.1111/j.1471-4159.1983.tb08082.x
复制
发表时间：
1983
影响因子：
4.7
通讯作者：
Hawkins,RA
中科院分区：
文献类型：
--
作者：
Mans,AM;Biebuyck,JF;Davis,DW;Bryan,RM;Hawkins,RA
在门腔静脉端侧吻合的大鼠中，用[2-14C]葡萄糖测量局部脑葡萄糖利用率。实验在建立门腔分流术后4~8周在两组大鼠身上进行。其中一组被麻醉并给予N2O：O2(70：30)，而另一组是清醒的、没有压力的、不知道实验的。在两组中，门腔分流术后几乎所有脑结构的葡萄糖利用率平均下降了20%。结果明确地表明，在没有明显神经异常的情况下，大脑能量代谢降低。
Regional cerebral glucose utilization was measured using [2‐14C]glucose in rats with an end‐to‐side portacaval anastomosis. The experiments were conducted in two groups of rats 4 to 8 weeks after portacaval shunting was established. One group was paralyzed and given N2O:O2(70:30), whereas the other was conscious, unstressed, and unaware of the experiment. In both groups the rate of glucose utilization was decreased in almost all brain structures by an average of 20% after portacaval shunting. The results showed definitively that cerebral energy metabolism was reduced at a time when there were no obvious neurological abnormalities.