Cytotoxic chromenes from Myriactis humilis
Cytotoxic chromenes from Myriactis humilis
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DOI：
10.1055/s-2005-864107
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发表时间：
2005-04-01
期刊：
影响因子：
2.7
通讯作者：
Chen, IS
中科院分区：
文献类型：
--
作者：
Chen, JJ;Duh, CY;Chen, IS
从矮密果（Myriactis humilis）全草中分离得到2个新的色烯化合物myriachromene和2，2-二甲基-6，7-亚甲二氧基-2H-色烯，以及10个已知化合物α-生育酚醌、α-生育酚乙酸酯、二苯砜、β-胡萝卜素、β-谷甾醇、β-谷甾醇酮、香草醛和香草酸。通过光谱分析确定了这些新化合物的结构。在分离物中，四种化合物在体外对P-388或HT-29细胞系表现出细胞毒性（ED 50值< 4 μ g/mL）。
Two new chromenes, myriachromene and 2,2-dimethyl-6,7-methylenedioxy-2H-chromene, together with ten known compounds including alpha-tocopherylquinone, alpha-tocopherol acetate, diphenyl sulfone, beta-carotene, chondrillasterol, beta-sitosterol, beta-sitostenone, vanillin, and vanillic acid were isolated from the whole plant of Myriactis humilis. The structures of these new compounds were determined through spectral analyses. Among the isolates, four compounds exhibited cytotoxicity (ED50 values < 4 mu g/mL) against P-388 or HT-29 cell lines in vitro.