Expression of aldehyde dehydrogenase 1 (ALDH1) in endometrioid adenocarcinoma and its clinical implications
Expression of aldehyde dehydrogenase 1 (ALDH1) in endometrioid adenocarcinoma and its clinical implications
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DOI：
10.1111/j.1349-7006.2011.01864.x
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发表时间：
2011-04-01
期刊：
影响因子：
5.7
通讯作者：
Morii, Eiichi
中科院分区：
文献类型：
--
作者：
Rahadiani, Nur;Ikeda, Jun-ichiro;Morii, Eiichi
乙醛脱氢酶1（ALDH 1）在干/祖细胞中表达，包括各种器官的癌症起始细胞（CIC）。在本研究中，ALDH 1的表达进行了免疫组化检查在子宫卵巢样腺癌。ALDH 1在一小部分肿瘤细胞中表达，并且这些ALDH 1表达细胞比ALDH 1非表达细胞更不成熟。表达ALDH 1的细胞（ALDH 1-hi）比ALDH 1-lo细胞更具致瘤性，对抗癌药物具有抗性，更具侵袭性。分选的ALDH 1-hi细胞的培养产生ALDH 1-hi和ALDH 1-lo细胞，而ALDH 1-lo细胞仅产生ALDH-lo细胞。临床上，ALDH 1在肿瘤细胞中的高表达与T分类、淋巴结浸润、复发和患者预后相关。ALDH 1高表达患者的生存率低于低表达患者（P = 0.015，P = 0.010），ALDH 1高表达是预后不良的独立因素。乙醛脱氢酶1可作为子宫内膜样腺癌的CIC标志物。（Cancer Sci 2011; 102：903-908）
Aldehyde dehydrogenase 1 (ALDH1) is expressed in stem/progenitor cells, including cancer-initiating cells (CIC) of various organs. In the present study, ALDH1 expression was immunohistochemically examined in uterine endometrioid adenocarcinoma. The ALDH1 was expressed in a small portion of tumor cells, and these ALDH1-expressing cells were less mature than ALDH1-non-expressing cells. The ALDH1-expressing (ALDH1-hi) cells were more tumorigenic, resistant to anti-cancer agents and more invasive than ALDH1-lo cells. Culture of the sorted ALDH1-hi cells yielded both ALDH1-hi and ALDH1-lo cells, whereas ALDH1-lo cells yielded ALDH-lo cells alone. Clinically, a high-level of ALDH1 expression in tumor cells was correlated with T category, lymphatic invasion, recurrence and prognosis of patients. Patients with high ALDH1 expression showed poorer prognoses than those with low expression (P = 0.015 for disease-free survival [DFS] and P = 0.010 for overall survival [OS]), and high ALDH1 expression was an independent factor for poor prognosis. Aldehyde dehydrogenase 1 is a candidate for CIC marker for uterine endometrioid adenocarcinoma. (Cancer Sci 2011; 102: 903-908)