Lesions of the basolateral amygdala disrupt conditioning based on the retrieved representations of motivationally significant events
Lesions of the basolateral amygdala disrupt conditioning based on the retrieved representations of motivationally significant events
复制标题
DOI：
10.1523/jneurosci.1647-06.2006
复制
发表时间：
2006-08-09
影响因子：
5.3
通讯作者：
Killcross, Simon
中科院分区：
文献类型：
--
作者：
Dwyer, Dominic M.;Killcross, Simon
一个最近的观点（Blundell等人，二○ ○一年;二○ ○三年; Killcross and Blundell，2002; Balleine et al. 2003）对杏仁核基底外侧区（BLA）功能的研究表明，它在表征动机重要事件的感觉特征方面起着重要作用。这预示着损伤的BLA将不会产生递减的性能在空调程序的基础上形成的中性事件的感官方面之间的关联，但会干扰空调的基础上中性线索和动机之间的关联显着的事件。这一预测是支持的证据表明，BLA病变没有影响的感觉预处理程序（实验1A），使用中性线索，但BLA病变没有显着损害代表介导的条件反射（实验1B）时，目标线索是动机显着的培训时间。这些结果表明，动物与病变的BLA可以代表的感觉方面的中性事件，但不是感官方面的动机显着的事件。
One recent perspective (Blundell et al., 2001; 2003; Killcross and Blundell, 2002; Balleine et al. 2003) on the function of the basolateral region of the amygdala (BLA) suggests that it plays an important role in the representation of the sensory features of motivationally significant events. This predicts that lesions of the BLA will not produce a decrement in performance in conditioning procedures based on the formation of associations between the sensory aspects of neutral events but will interfere with conditioning based on associations between neutral cues and motivationally significant events. This prediction is supported by the evidence that BLA lesions were without effect on a sensory preconditioning procedure (experiment 1A) that used neutral cues but that BLA lesions did significantly impair representation-mediated conditioning (experiment 1B) when the target cues were motivationally significant at the time of training. These results demonstrate that animals with lesions of the BLA can represent the sensory aspects of neutral events but not the sensory aspects of motivationally significant events.