Free water imaging of the cholinergic system in dementia with Lewy bodies and Alzheimer's disease.
Free water imaging of the cholinergic system in dementia with Lewy bodies and Alzheimer's disease.
复制标题
路易体痴呆和阿尔茨海默氏病胆碱能系统的自由水成像。
DOI：
10.1002/alz.13034
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Schumacher J
中科院分区：
文献类型：
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作者：
Schumacher J
引言Meynert基底核（NBM）的皮质胆碱能投射的退化是路易体痴呆（DLB）和阿尔茨海默病（AD）的特征，而脚桥核（PPN）到丘脑的胆碱能投射的参与不太清楚. METHODS我们在以下病例中使用自由水校正扩散张量成像（DTI）模型研究了两种胆碱能投射系统：46例AD、48例DLB、35例轻度认知障碍（MCI）伴AD、38例轻度认知障碍伴路易体和71例对照。与对照组相比，痴呆组和MCI组的NBM-皮质通路中的游离水增加，并与认知相关。沿着PPN-丘脑束的自由水沿着仅在DLB中增加，并且与幻视相关。结果在一个独立的队列中得到了很大程度的复制。来自PPN的丘脑胆碱能输入似乎在DLB中更有选择性地受到影响，并且可能与视幻觉有关。Highlights在AD和DLB中，NBM-皮质胆碱能通路中的自由水增加。NBM-皮质通路完整性与整体认知性能相关。PPN-丘脑胆碱能通路中的自由水仅在DLB中增加，而不是AD。PPN-丘脑通路完整性可能与DLB中的幻视有关。
INTRODUCTIONDegeneration of cortical cholinergic projections from the nucleus basalis of Meynert (NBM) is characteristic of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD), whereas involvement of cholinergic projections from the pedunculopontine nucleus (PPN) to the thalamus is less clear.METHODSWe studied both cholinergic projection systems using a free water‐corrected diffusion tensor imaging (DTI) model in the following cases: 46 AD, 48 DLB, 35 mild cognitive impairment (MCI) with AD, 38 MCI with Lewy bodies, and 71 controls.RESULTSFree water in the NBM‐cortical pathway was increased in both dementia and MCI groups compared to controls and associated with cognition. Free water along the PPN‐thalamus tract was increased only in DLB and related to visual hallucinations. Results were largely replicated in an independent cohort.DISCUSSIONWhile NBM‐cortical projections degenerate early in AD and DLB, the thalamic cholinergic input from the PPN appears to be more selectively affected in DLB and might associate with visual hallucinations.HighlightsFree water in the NBM‐cortical cholinergic pathways is increased in AD and DLB.NBM‐cortical pathway integrity is related to overall cognitive performance.Free water in the PPN‐thalamus cholinergic pathway is only increased in DLB, not AD.PPN‐thalamus pathway integrity might be related to visual hallucinations in DLB.