Comparative efficacy of Bentonite clay, activated charcoal and Trichosporon mycotoxinivorans in regulating the feed-to-tissue transfer of mycotoxins
Comparative efficacy of Bentonite clay, activated charcoal and Trichosporon mycotoxinivorans in regulating the feed-to-tissue transfer of mycotoxins
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DOI：
10.1002/jsfa.8533
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发表时间：
2018-02-01
影响因子：
4.1
通讯作者：
Akhter, Masood
中科院分区：
文献类型：
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作者：
Bhatti, Sheraz Ahmed;Khan, Muhammad Zargham;Akhter, Masood
动物产品和副产品中的霉菌毒素污染是对食品和饲料工业的持续威胁。采用高效液相色谱法（HPLC）测定了黄曲霉毒素B1（AFB 1）和赭曲霉毒素A（OTA）残留量，结果表明，黄曲霉毒素B1（AFB 1）和赭曲霉毒素A（OTA）残留量随添加量的增加而增加。在黄曲霉毒素B_1污染的日粮中添加BN和AC，可使黄曲霉毒素B_1在肝脏中的残留量分别下降41-87%和16-72%。然而，加入TM作为AFB 1结合剂时，这种降低不显著。BN和AC对OTA残留的保护作用不显著，而TM和OTA联合饲喂组的OTA残留量显著降低（38-84%）。结论BN和AC降低肝脏AFB 1残留的效果顺序为BN>AC>TM，而对OTA的效果顺序为TM>BN>AC。本研究的结果表明，根据目标真菌毒素的性质，多种真菌毒素结合剂/解毒剂的混合物应纳入动物饲料。(c)2017年化学工业协会
BACKGROUNDMycotoxins contamination in animal products and by-products is a persistent threat to the food and feed industry. The present study was designed to evaluate the comparative inhibitory effects of Bentonite (BN), activated charcoal (AC) and a newly discovered yeast, Trichosporon mycotoxinivorans (TM), against feed-to-tissue transfer of mycotoxins.RESULTSA dose dependent increase as determined by HPLC, in the residues of aflatoxin B1 (AFB1) and ochratoxin A (OTA) was exhibited in the groups of birds fed AFB1 and OTA alone. The dietary addition of BN and AC to AFB1-contaminated diets resulted in a 41-87% and 16-72% decrease in AFB1 residues in liver of the birds, respectively. However, this decrease was non-significant with addition of TM as AFB1 binder. A partial to non-significant protection was observed by dietary BN and AC, against OTA residues, while a significant decrease in OTA residues (38-84%) was noted in TM-OTA co-fed groups.CONCLUSIONThe order of efficacy in terms of lowering AFB1 residues in the liver was BN>AC>TM, while against OTA it was TM>BN>AC. The findings of present study suggest that, based upon the nature of target mycotoxins, a mixture of multi-mycotoxins binders/detoxifiers should be incorporated in the animal feeds. (c) 2017 Society of Chemical Industry