A screw-actuated pneumatic valve for portable, disposable microfluidics
A screw-actuated pneumatic valve for portable, disposable microfluidics
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DOI：
10.1039/b811526e
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发表时间：
2009-01-01
期刊：
影响因子：
6.1
通讯作者：
Wu, Hongkai
中科院分区：
文献类型：
--
作者：
Zheng, Yizhe;Dai, Wen;Wu, Hongkai
这项工作描述了一种简单而廉价的方法，用于控制奎克小组发明的气动阀，以将整个系统用于便携式和一次性微流体装置。阀门由两部分组装而成。一种是通过多层软光刻形成的聚二甲基硅氧烷（PDMS）通道。另一个是一个聚甲基丙烯酸甲酯（PMMA）框架与机器螺丝的压力控制。将螺钉旋入控制通道入口（充满水并覆盖有薄PDMS膜），通过在控制通道中产生压力来驱动阀门。该方法避免了笨重和昂贵的外部压力控制设施，并且可以容易地集成到便携式和一次性设备中。
This work describes a simple and inexpensive approach for controlling the pneumatic valves that were invented in Quake's group to miniaturize the whole system for portable and disposable microfluidic devices. The valves are assembled from two parts. One is the polydimethylsiloxane (PDMS) channels formed by multilayer soft lithography. The other is a polymethylmethacrylate (PMMA) frame with machine screws for pressure control. Turning the screws into the control channel inlet (filled with water and covered with a thin PDMS membrane) actuates the valve by creating pressure in the control channel. This method avoids the bulky and expensive external pressure-control facilities and can be easily integrated into portable and disposable devices.