Rearrangement and degradation of cephalosporins and penicillins in the presence of mercury(II) trifluoroacetate
Rearrangement and degradation of cephalosporins and penicillins in the presence of mercury(II) trifluoroacetate
复制标题
DOI：
10.1021/ol9911627
复制
发表时间：
2000-01-27
期刊：
影响因子：
5.2
通讯作者：
Gunda, TE
中科院分区：
文献类型：
--
作者：
Gunda, TE
[图解]头孢菌素类和青霉素类药物在甲醇中三氟乙酸汞的影响下重排为非β-内酰胺类产品。在这两种情况下，重排的机制不同。而开链氨基丙烯酸衍生物4是由头孢菌素产生的，恶唑7和丙酰胺6衍生物是由青霉素产生的。
[GRAPHICS]Cephalosporins and penicillins rearrange under the influence of mercury(ll) trifluoroacetate in methanol to non-beta-lactam products. The mechanisms of the rearrangements are different in the two cases. Whereas the open chain aminoacrylic acid derivative 4 is produced from cephalosporins, the oxazole 7 and the propionamide 6 derivatives are the products from penicillins.