Serum sLYVE-1 is not associated with coronary disease but with renal dysfunction: a retrospective study
Serum sLYVE-1 is not associated with coronary disease but with renal dysfunction: a retrospective study
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血清 sLYVE-1 与冠心病无关，但与肾功能障碍相关：一项回顾性研究
DOI：
10.1038/s41598-019-47367-2
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发表时间：
2019
影响因子：
4.6
通讯作者：
Zhang Ruiyan
中科院分区：
文献类型：
--
作者：
Dai Daopeng;Huang Chunkai;Ni Jinwei;Zhu Zhenbin;Han Hui;Zhu Jinzhou;Zhang Ruiyan
最近的证据表明，淋巴管内皮透明质酸受体（LYVE-1）涉及慢性炎症和淋巴免疫反应。LYVE-1的可溶形式（sLYVE-1）是在包括癌症和慢性炎症的病理条件下通过LYVE-1的胞外域脱落产生的。本研究纳入了2015年5月至2015年9月接受冠状动脉造影的1014例连续患者，以研究血清sLYVE-1是否与冠状动脉疾病（CAD）及其伴随疾病（包括慢性肾脏疾病（CKD））相关。结果显示，冠心病组与非冠心病组sLYVE-1水平无显著性差异。然而，与eGFR正常的患者相比，在肾功能不全患者中观察到sLYVE-1水平显著较高。结果在259例患者中进行了验证，根据估计的肾小球滤过率（eGFR）将患者分为4组，简单的双变量相关分析显示，Lg[sLYVE-1]与eGFR（r =-0.358，p < 0.001）和胱抑素C（r = 0.303，p < 0.001）呈负相关。多因素Logistic回归分析显示，Lg[sLYVE-1]升高是肾功能不全的独立决定因素（OR = 1.633，p = 0.007）。因此，当血清sLYVE-1用作检测慢性炎症和癌症等病理状况的生物标志物时，应考虑肾功能。sLYVE-1在肾功能中的确切作用有待进一步研究。
Recent evidence has indicated that the lymphatic vessel endothelial hyaluronan receptor (LYVE-1) is implicated in chronic inflammation and the lymphatic immune response. The soluble form of LYVE-1 (sLYVE-1) is produced by ectodomain shedding of LYVE-1 under pathological conditions including cancer and chronic inflammation. In this study, 1014 consecutive patients who underwent coronary angiography from May 2015 to September 2015 were included to investigate whether serum sLYVE-1 is associated with coronary artery disease (CAD) and its concomitant diseases includes chronic kidney disease (CKD). Results showed that there was no significant difference in sLYVE-1 levels between patients with CAD and without. However, a significantly higher level of sLYVE-1 was seen in patients with renal dysfunction compared to those with a normal eGFR. Results were validated in a separate cohort of 259 patients who were divided into four groups based on their kidney function assessed by estimated glomerular filtration rate (eGFR).Simple bivariate correlation analysis revealed that Lg[sLYVE-1] was negatively correlated with eGFR (r = −0.358,p< 0.001) and cystatin C (r = 0.303,p< 0.001). Multivariable logistic regression analysis revealed that the increase in Lg[sLYVE-1] was an independent determinant of renal dysfunction (odds ratio = 1.633,p= 0.007). Therefore, renal function should be considered when serum sLYVE-1 is used as a biomarker for the detection of pathological conditions such as chronic inflammation and cancer. Further study is required to elucidate the exact role of sLYVE-1 in renal function.