Breast cancer: a model system for studying the neuroendocrine role of pineal melatonin in oncology.
Breast cancer: a model system for studying the neuroendocrine role of pineal melatonin in oncology.
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乳腺癌：研究松果体褪黑激素在肿瘤学中神经内分泌作用的模型系统。
DOI：
10.1042/bst0200309
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发表时间：
1992
影响因子：
3.9
通讯作者：
Wilson,ST
中科院分区：
文献类型：
--
作者：
Blask,DE;Lemus-Wilson,AM;Wilson,ST
在过去的十年里，我们对肿瘤反应性致癌的细胞和分子内分泌学的认识已经取得了巨大的进展。乳头状乳腺癌霍特homiones和1 iormone-indirc。自分泌生长因子在生殖系统重要肿瘤的生长机制中起着重要作用。事实上，大多数乳腺癌可能在某种程度上依赖于雌激素、雌激素诱导生长因子和/或催乳素来生长[1，21]。褪黑激素;哺乳动物松果体的高级分泌产物，是许多哺乳动物生殖生理的重要神经内分泌调节剂。在包括大鼠在内的许多物种中，这种吲哚胺抑制正常生殖道的发育和生长[13]。我在此。我一直在用致癌物阴性的动物td乳腺癌在体内，因为\\ell;是人类;在乳腺癌细胞系在7 ritr 0，作为模型系统研究褪黑激素的神经内分泌作用，在肿瘤发生1-1。S I.下面的讨论将回顾最近的一些研究结果，这些研究结果支持褪黑激素是一种抑瘤激素的假说，因为它能抑制类固醇激素、多肽激素和生长激素的促有丝分裂作用。
‘I ‘remendous idwinces have been made w ithin the last decade in our knowledge of the cellular and molecular endocrinology of hormone-responsive carcinogenesis. pilrticularly breast cancer. Hoth homiones and 1iormone-indirc. ible autocrine growth factors play a prominent role in the mechanisms rnediating the growth of this important neoplasm of the reproductive system. In fjict most breast cancers probably rely to some degree upon oestrogen, oestrogen-inducible growth factors and/or prolactin for their growth [1, 21. hlelatonin, the m; i. ior secretory product of the rnammalian pineal gland, is an important neuroendocrine regulator of reproductive physiology in many mammalian species. In R number of these species including the rat, this indoleamine inhibits the development and growth of the normal reproductive tract 13].‘I’herefore. me hiive been using animals with carcinogen-indiIc. td mammary cancers in viva, as\\ell; is hum; in breast cancer cell lines in 7ritr0, as model systems for studying the neuroendocrine role of melatonin in oncogenesis 1-1. S I. The following discussion mill review some recent findings that support the hypothesis that melatonin is an oncostatic hornioiw by virtue of its iibility to inhibit the mitogenic action of steroids;~ nd polypeptide hormones and growth tictors.