Silver-Decorated Polymeric Micelles Combined with Curcumin for Enhanced Antibacterial Activity
Silver-Decorated Polymeric Micelles Combined with Curcumin for Enhanced Antibacterial Activity
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银装饰的聚合物胶束与姜黄素结合增强抗菌活性
DOI：
10.1021/acsami.7b03347
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发表时间：
2017-05-24
影响因子：
9.5
通讯作者：
Liu, Jianfeng
中科院分区：
文献类型：
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作者：
Huang, Fan;Gao, Yang;Liu, Jianfeng
由于多重耐药菌引起的复杂感染的日益普遍，开发创新的、高效的抗菌药物势在必行。在这项工作中，我们设计了一种新型的聚合物胶束，同时修饰银纳米粒子和包封姜黄素作为一种组合策略，以提高抗菌效率。在所构建的复合体系中，银纳米粒子被聚天冬氨酸（PAsp）吸附在胶束壳层中，银离子被原位还原。同时，天然姜黄素通过疏水作用被包裹在胶束的聚己内酯（PCL）核中。该方法在抑制银纳米粒子聚集的同时，提高了姜黄素的水溶性，对革兰氏阴性铜绿假单胞菌和革兰氏阳性金黄色葡萄球菌的抑菌活性均高于银修饰胶束和姜黄素负载胶束，这是由于银纳米粒子和姜黄素协同抑菌作用的结果。此外，所制备的复合胶束具有良好的生物相容性和较低的溶血活性。因此，本研究为合理设计联合用药策略，有效预防细菌感染提供了新的途径。
Because of the mounting prevalence of complicated infections induced by multidrug-resistant bacteria, it is imperative to develop innovative and efficient antibacterial agents. In this work, we design a novel polymeric micelle for simultaneous decorating of silver nanoparticles and encapsulating of curcumin as a combination strategy to improve the antibacterial efficiency. In the constructed combination system, silver nanoparticles were decorated in the micellar shell because of the in situ reduction of silver ions, which were absorbed by the poly(aspartic acid) (PAsp) chains in the shell. Meanwhile, natural curcumin was encapsulated into the poly(epsilon-caprolactone) (PCL) core of the micelle through hydrophobic interaction. This strategy could prevent aggregation of silver nanoparticles and improve the water solubility of curcumin at the same time, which showed enhanced antibacterial activity toward Gram-negative P.aeruginosa and Gram-positive S.aureus compared with sliver-decorated micelle and curcumin-loaded micelle alone, due to the cooperative antibacterial effects of the silver nanoparticles and curcumin. Furthermore, the achieved combinational micelles had good biocompatibility and low hemolytic activity. Thus, our study provides a new pathway in the rational design of combination strategy for efficiently preventing the ubiquitous bacterial infections.