The Role of Gastrin and CCK Receptors in Pancreatic Cancer and other Malignancies.
The Role of Gastrin and CCK Receptors in Pancreatic Cancer and other Malignancies.
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DOI：
10.7150/ijbs.14952
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发表时间：
2016
影响因子：
9.2
通讯作者：
Moody TW
中科院分区：
文献类型：
--
作者：
Smith JP;Fonkoua LK;Moody TW
胃肠道（GI）肽胃泌素是胃壁细胞释放胃酸的重要调节剂，在胃肠道生长中也起着重要作用。很明显，胃泌素及其相关肽胆囊收缩素（CCK）也通过激活胆囊收缩素-B（CCK-B）受体与胃肠道癌症以及其他恶性肿瘤的生长显着相关。有趣的是，胃泌素在胚胎胰腺中表达，但在成人胰腺中不表达;然而，胃泌素在胰腺癌中重新表达，它通过自分泌机制刺激这种恶性肿瘤的生长。用选择性抗体或受体拮抗剂下调胃泌素或干扰其与CCK受体的界面的策略有望用于治疗胰腺癌和其他胃泌素响应性肿瘤。
The gastrointestinal (GI) peptide gastrin is an important regulator of the release of gastric acid from the stomach parietal cells and it also plays an important role in growth of the gastrointestinal tract. It has become apparent that gastrin and its related peptide cholecystokinin (CCK) are also significantly involved with growth of GI cancers as well as other malignancies through activation of the cholecystokinin-B (CCK-B) receptor. Of interest, gastrin is expressed in the embryologic pancreas but not in the adult pancreas; however, gastrin becomes re-expressed in pancreatic cancer where it stimulates growth of this malignancy by an autocrine mechanism. Strategies to down-regulate gastrin or interfere with its interface with the CCK receptor with selective antibodies or receptor antagonists hold promise for the treatment of pancreatic cancer and other gastrin - responsive tumors.