Thiersinines A and B:: Novel antiinsectan indole diterpenoids from a new fungicolous Penicillium species (NRRL 28147)
Thiersinines A and B:: Novel antiinsectan indole diterpenoids from a new fungicolous Penicillium species (NRRL 28147)
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DOI：
10.1021/ol026424a
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发表时间：
2002-09-05
期刊：
影响因子：
5.2
通讯作者：
Dowd, PF
中科院分区：
文献类型：
--
作者：
Li, C;Gloer, JB;Dowd, PF
[图表]两个新的抗昆虫吲哚二萜类化合物，thiersinines A（1）和B（2），沿着7个已知的paxilline型化合物，从一个新的青霉属物种（P. thiersii NRRL 28147）的有机提取物中分离出来。化合物1和2的结构通过2D NMR数据分析确定。Thiersinine A和B具有独特的螺环亚基，这在以前已知的这类化合物中是前所未有的。这两种化合物对秋粘虫（草地贪夜蛾）表现出有效的活性。
[GRAPHICS]Two novel antiinsectan indole diterpenoids, thiersinines A (1) and B (2), along with seven known paxilline-type compounds, were isolated from organic extracts of a new Penicillium species (P. thiersii NRRL 28147). The structures of 1 and 2 were determined by analysis of 2D NMR data. Thiersinines A and B possess a unique spirocyclic subunit that is unprecedented in previously known compounds of this class. Both compounds exhibit potent activity against the fall armyworm (Spodoptera frugiperda).