Formative Investigation of Acceptability of Typhoid Vaccine during a Typhoid Fever Outbreak in Neno District, Malawi
Formative Investigation of Acceptability of Typhoid Vaccine during a Typhoid Fever Outbreak in Neno District, Malawi
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DOI：
10.4269/ajtmh.14-0067
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发表时间：
2014-10-01
影响因子：
3.3
通讯作者：
Mintz, Eric D.
中科院分区：
文献类型：
--
作者：
Blum, Lauren S.;Dentz, Holly;Mintz, Eric D.
据估计，伤寒每年影响2200万人，并导致全球21.6万人死亡。我们在2010年8月和9月进行了一项调查，以检查伤寒疫苗在马拉维Neno区的可接受性，那里正在发生伤寒疫情。我们使用了定性的方法，包括自由罗列练习、关键线人和深入访谈以及小组讨论。受访者将疾病与暴露在“大风”中联系在一起，据信是通过空气传播的。伤寒被认为是极其危险的，因为它的迅速传播，它所产生的令人衰弱的情况，相关的死亡人数，以及人们认为它具有高度传染性。受访者对水、卫生和个人卫生(洗涤)干预的有效性持怀疑态度。人们认为伤寒的严重性和对暴露的恐惧，对洗涤措施有效性的不确定性，以及对疫苗预防疾病有效性的普遍信念，导致在疫情爆发期间对接种伤寒疫苗产生了压倒性的兴趣。
Typhoid fever affects an estimated 22 million people annually and causes 216,000 deaths worldwide. We conducted an investigation in August and September 2010 to examine the acceptability of typhoid vaccine in Neno District, Malawi where a typhoid outbreak was ongoing. We used qualitative methods, including freelisting exercises, key informant and in-depth interviews, and group discussions. Respondents associated illness with exposure to "bad wind," and transmission was believed to be airborne. Typhoid was considered extremely dangerous because of its rapid spread, the debilitating conditions it produced, the number of related fatalities, and the perception that it was highly contagious. Respondents were skeptical about the effectiveness of water, sanitation, and hygiene (WaSH) interventions. The perceived severity of typhoid and fear of exposure, uncertainty about the effectiveness of WaSH measures, and widespread belief in the efficacy of vaccines in preventing disease resulted in an overwhelming interest in receiving typhoid vaccine during an outbreak.