ELECTROLYTE AND WATER-BALANCE IN YOUNG SPONTANEOUSLY HYPERTENSIVE RATS
ELECTROLYTE AND WATER-BALANCE IN YOUNG SPONTANEOUSLY HYPERTENSIVE RATS
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DOI：
10.1161/01.hyp.4.6.908
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发表时间：
1982-01-01
期刊：
影响因子：
8.3
通讯作者：
KLEMMER, PJ
中科院分区：
文献类型：
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作者：
BEIERWALTES, WH;ARENDSHORST, WJ;KLEMMER, PJ
在代谢平衡研究中，测量了Okamoto-Aoki品系的自发性高血压大鼠（SHR）和年龄匹配的3-13周龄的Wistar京都大鼠（WKY）的Na、K和水的摄入和排泄。而喂养他们通常的食物，年轻的SHR表现出排泄的差异相比，WKY消耗基本等量的食物和水。由于尿排泄率较低，SHR在第4-6周和第6-7周的钠和水排泄率（占摄入量的百分比）分别显著降低。SHR在4-5周时排钾量较少。显然，SHR在高血压早期比血压正常、年龄匹配的WKY保留更多的尿钠、钾和水。8周龄后，电解质和水的排泄分数菌株之间没有明显差异。在另一组大鼠中，限制Na摄入，并从3-13周龄进行观察。虽然SHR排泄的钠稍少，但累积钠平衡在SHR和WKY中相似。限钠可减缓9周龄以下SHR的动脉压升高，降低10-13周龄SHR的高血压程度。在后者的年龄，动脉压不高，在钠限制SHR的SHR的标准钠饮食，但它高于任何WKY组。因此，限制钠摄入可延缓SHR高血压的发生，但不能预防SHR高血压的发生。
In metabolic balance studies the intake and excretion of Na, K and water were measured in spontaneously hypertensive rats (SHR) of the Okamoto-Aoki strain and age-matched Wistar Kyoto rats (WKY) that were 3-13 wk of age. While fed their usual chow, young SHR exhibited differences in excretion as compared to WKY consuming essentially equivalent amounts of food and water. Fractional Na and water excretion (percent of amount ingested) by SHR wre significantly less during wk 4-6 and 6-7, respectively, due to lower rates of urinary excretion. Potassium excretion was less in SHR at 4-5 wk. Apparently, SHR retain more urinary Na, K and water during an early phase of hypertension than normotensive, age-matched WKY. After 8 wk of age, fractional excretion of electrolytes and water did not differ appreciably between strains. In another group of rats, Na intake was restricted and observations were made from 3-13 wk of age. Although SHR excreted slightly less Na, cumulative Na balance was similar in SHR and WKY. Na restriction slowed the increase in arterial pressure in SHR younger than 9 wk of age and reduced the magnitude of the hypertension in 10-13 wk old SHR. At the latter age, arterial pressure was not as high in Na-restricted SHR as in SHR on the standard Na diet, but it was elevated above that in either WKY groups. Thus, dietary Na restriction retards the development, but does not prevent the hypertension in SHR.