Daily exercise attenuated the sympathetic component of the spontaneous arterial baroreflex control of heart rate in hypertensive rats
Daily exercise attenuated the sympathetic component of the spontaneous arterial baroreflex control of heart rate in hypertensive rats
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DOI：
10.1081/ceh-100100095
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发表时间：
2000-08-01
影响因子：
12.3
通讯作者：
DiCarlo, SE
中科院分区：
文献类型：
--
作者：
Collins, HL;Rodenbaugh, DW;DiCarlo, SE
在22只雌性自发性高血压大鼠[12只久坐和10只每日自发跑步]中，研究了每日自发跑步对自发性动脉压力反射控制心率的交感神经和副交感神经成分的影响。经过8周的久坐控制或每天自发运行，动物长期配备动脉导管。每日自发跑步导致心脏重量/体重比增加（5.2+/-0.27 vs 4.3+/-0.01 g/kg）和静息心动过缓（321+/-8 bpm vs 360+/-6）。在三种实验条件下检查动脉压的自发变化和心率的反射反应：1）阻断前，2）阻断β（1）-肾上腺素能受体后，3）阻断毒蕈碱胆碱能受体后。每日自发跑步减弱了动脉压力反射控制心率的自发增益（56%）。在毒蕈碱胆碱能受体阻断后，每日自发跑步大鼠的自发增益仍然减少（57%）。相比之下，β（1）-肾上腺素能受体阻断后，久坐对照组和每日自发跑步组动物的自发增益没有差异。结果表明，日常自发运行减少交感神经成分，导致明显更大的影响副交感神经成分的自主动脉压力反射控制的心率。
The influence of daily spontaneous running on the sympathetic and parasympathetic components of the spontaneous arterial baroreflex control of heart rate was examined in 22 female spontaneously hypertensive rats [12 sedentary and 10 daily spontaneous running]. Following 8 weeks of sedentary control or daily spontaneous running, animals were chronically instrumented with an arterial catheter. Daily spontaneous running resulted in an increased heart weight/body weight ratio (5.2+/-0.27 vs 4.3+/-0.01 g/kg) and a resting bradycardia (321+/-8 bpm vs 360+/-6). The spontaneous changes in arterial pressure and the reflex responses of heart rate were examined under three experimental conditions: 1) pre-blockade, 2) following beta(1)-adrenergic receptor blockade, and 3) following muscarinic-cholinergic receptor blockade. Daily spontaneous running attenuated the spontaneous gain of the arterial baroreflex control of heart rate (56%). After muscarinic-cholinergic receptor blockade, the spontaneous gain remained reduced in daily spontaneous running rats (57%). In contrast, after beta(1)-adrenergic receptor blockade the spontaneous gain was not different between sedentary control and daily spontaneous running animals. Results demonstrate that daily spontaneous running decreased the sympathetic component resulting in an apparently greater influence of the parasympathetic component on the spontaneous arterial baroreflex control of heart rate.