Beta-endorphin: synthesis and properties of analogs with replacement of lysine residues by arginine.
Beta-endorphin: synthesis and properties of analogs with replacement of lysine residues by arginine.
复制标题
β-内啡肽：用精氨酸替换赖氨酸残基的类似物的合成和性质。
DOI：
10.1111/j.1399-3011.1982.tb00895.x
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Nicolas,P
中科院分区：
文献类型：
--
作者：
Blake,J;Li,CH;Nicolas,P
采用固相法合成了人β-内啡肽类似物[Arg 9，19，24，28，29]-β-内啡肽（I）和[Arg 24，28，29]-β-内啡肽（II）。肽II具有母体分子的86%的镇痛效力和216%的受体结合活性。肽I仅具有18%的镇痛效力，但其结合活性比人β-内啡肽的结合活性大三倍以上。
Human β‐endorphin analogs, [Arg9,19,24,28,29]‐β‐endorphin (I) and [Arg24,28,29]‐β‐endorphin (II), have been synthesized by the solid‐phase method. Peptide II had 86% of the analgesic potency and 216% of the receptor binding activity of the parent molecule. Peptide I had only 18% analgesic potency but its binding activity was more than three time greater than that of human β‐endorphin.