Efficient synthesis of 2'-deoxynucleoside 3'-C-phosphonates: reactivity of geminal hydroxyphosphonate moiety.
Efficient synthesis of 2'-deoxynucleoside 3'-C-phosphonates: reactivity of geminal hydroxyphosphonate moiety.
复制标题
2-脱氧核苷3-C-膦酸酯的有效合成：孪生羟基膦酸酯部分的反应性。
DOI：
10.1080/15257770008035038
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Rosenberg,I
中科院分区：
文献类型：
--
作者：
Kralikova,S;Budyysinsky,M;Masojidkova,M;Rosenberg,I
在这份报告中，我们提出了一种新的，简单的方法来合成的3′-C-膦酸酯衍生物的所有四个基本的2′-脱氧核苷在完全保护和脱保护的形式。研究了位于核苷3′-碳原子上的偕羟基膦酸酯部分的反应性，并将其用于制备短寡核苷酸，即二核苷单磷酸类似物。
In this report we present a novel, simple way for the synthesis of 3′-C-phosphonate derivatives of all four basic 2′-deoxynucleosides in both fully protected and deprotected forms. The reactivity of the geminal hydroxy phosphonate moiety located at the 3′-carbon atom of the nucleoside was studied with respect to the use of this type of nucleoside phosphonic acid for the preparation of short oligonucleotides, namely, dinucleoside monophosphate analogues.