"Alveolar" and whole lung phospholipids of the developing fetal lamb lung.
"Alveolar" and whole lung phospholipids of the developing fetal lamb lung.
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发育中的胎儿羔羊肺的“肺泡”和全肺磷脂。
DOI：
10.1152/ajplegacy.1968.215.2.375
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发表时间：
1968
期刊：
影响因子：
--
通讯作者：
A. El
中科院分区：
文献类型：
--
作者：
T. Fujiwara;F. Adams;S. Sipos;A. El
福雷斯特·藤原哲郎亚当斯，莎拉·SIPOS，和阿德尔EL-SALAWY。发育中的胎羊肺的“CCA磷脂”和全肺磷脂。Am. J，Physiol.215（2）：375-382. 1968.-对17只胎羊的肺磷脂进行了定量和定性研究，通过两种技术：连续的肺洗涤（“肺泡”磷脂）和全肺匀浆（组织磷脂）。表面活性物质存在于呼吸开始之前的术语羔羊胎儿的肺泡。肺泡磷脂在几个方面不同于肺组织磷脂。肺泡磷脂酰胆碱的位置特异性分析显示，在长期胎儿的二棕榈酰磷脂酰胆碱的优势。从未成熟胎仔和肺冲洗液中获得的肺泡磷脂酰胆碱Jvere量可忽略不计，缺乏表面活性。肺泡磷脂酰胆碱从未成熟到过渡期增加50倍，另4倍到足月胎儿。妊娠期肺泡二饱和磷脂酰胆碱含量的增加与肺泡表面活性的出现有关。从过渡期和足月胎儿的肺冲洗液中回收磷脂酰二甲基乙醇胺。绵羊;胎儿;肺冲洗;成熟;表面活性剂;肺组织;磷脂;薄层色谱法;二饱和磷脂酰胆碱;磷脂酰二甲基乙醇胺
FUJIWARA, TETSURO, FORREST H. ADAMS, SARA SIPOS, AND ADEL EL-SALAWY. CCAlueular” and whole lung phospholipids of the developing fetal lamb lung. Am. J, Physiol. 215 (2): 375-382. 1968.-Quantitative and qualitative studies were performed on the lung phospholipids removed from 17 fetal lambs by two techniques: by sequential lung washings(“alveolar” phospholipids) and from whole lung homogenates(tissue phospholipids). Surface-active material is present in the alveoli of the term lamb fetuses prior to the onset of respiration. The alveolar phospholipids differ in several respects from lung tissue phospholipids. Analysis of the positional specificity of the alveolar phosphatidyl choline revealed a predominance of dipalmityl phosphatidyl choline in term fetuses. Negligible amounts of alveolar phosphatidyl choline Jvere obtained from immature fetuses and the lung washings lacked surface activity. Alveolar phosphatidyl choline in-creased 50-fold from immature to transitional fetuses and another 4-fold to term fetuses. The increase in alveolar disatu-rated phosphatidyl choline content during gestation correlated\Yell Gth the appearance of surface activity. Phosphatidyl dimethylethanolamine was recovered from the lung washings of transitional and term fetuses. sheep; fetus; lung wash; maturation; surfactant; lung tissue; phospholipids; thin layer chromatography(TLC); disaturated phosphatidyl choline; phosphatidyl dimethylethanolamine