Polygenic loading for major depression is associated with specific medical comorbidity.
Polygenic loading for major depression is associated with specific medical comorbidity.
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DOI：
10.1038/tp.2017.201
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发表时间：
2017-09-19
影响因子：
6.8
通讯作者：
Perlis RH
中科院分区：
文献类型：
--
作者：
McCoy TH;Castro VM;Snapper L;Hart K;Januzzi JL;Huffman JC;Perlis RH
严重抑郁障碍经常与内科疾病并存，这增加了共同承担遗传责任的可能性。最近发现了15个与抑郁症相关的新的遗传基因座，这使得对这个问题的直接研究成为可能。在两个学术医学中心参加生物库的个人队列中，我们计算了报告与抑郁症相关的风险基因座的多基因负载。然后，我们研究了这种加载与50组临床诊断或主题之间的关联，这些诊断或主题来自这些患者的电子健康记录，使用一种新的潜在Dirichilet分配应用来确定。有三个主题显示了整个实验范围内与抑郁易感性评分的关联；其中包括代表情绪和焦虑症患病率更高的诊断组，心脏缺血患病率更高，以及心力衰竭患病率降低。即使在没有被诊断为情绪障碍的个体中，后两种关联仍然存在。这种在生物库中对相关诊断进行分组的新方法的应用表明，抑郁症和心脏病的遗传风险是相同的，这种模式表明更大的缺血风险和更低的心力衰竭风险。
Major depressive disorder frequently co-occurs with medical disorders, raising the possibility of shared genetic liability. Recent identification of 15 novel genetic loci associated with depression allows direct investigation of this question. In cohorts of individuals participating in biobanks at two academic medical centers, we calculated polygenic loading for risk loci reported to be associated with depression. We then examined the association between such loading and 50 groups of clinical diagnoses, or topics, drawn from these patients' electronic health records, determined using a novel application of latent Dirichilet allocation. Three topics showed experiment-wide association with the depression liability score; these included diagnostic groups representing greater prevalence of mood and anxiety disorders, greater prevalence of cardiac ischemia, and a decreased prevalence of heart failure. The latter two associations persisted even among individuals with no mood disorder diagnosis. This application of a novel method for grouping related diagnoses in biobanks indicate shared genetic risk for depression and cardiac disease, with a pattern suggesting greater ischemic risk and diminished heart failure risk.
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影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
DOI：
10.1073/pnas.0307752101
发表时间：
2004-04-06
影响因子：
11.1
作者：
Griffiths, TL;Steyvers, M
通讯作者：
Steyvers, M
影响因子：
3.3
作者：
Lesperance, F;FrasureSmith, N;Talajic, M
通讯作者：
Talajic, M
影响因子：
120.7
作者：
Ducat, Lee;Philipson, Louis H.;Anderson, Barbara J.
通讯作者：
Anderson, Barbara J.
影响因子：
10.9
作者：
Cohen, Brandon E.;Martires, Kathryn J.;Ho, Roger S.
通讯作者：
Ho, Roger S.