Treatment of adolescents with early-onset schizophrenia spectrum disorders: in search of a rational, evidence-informed approach.
Treatment of adolescents with early-onset schizophrenia spectrum disorders: in search of a rational, evidence-informed approach.
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治疗患有早发性精神分裂症谱系障碍的青少年：寻找合理的、循证的方法。
DOI：
10.1097/yco.0b013e32835dcc2a
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发表时间：
2013
影响因子：
6.9
通讯作者：
Correll,ChristophU
中科院分区：
文献类型：
--
作者：
Schimmelmann,BennoG;Schmidt,StefanieJ;Carbon,Maren;Correll,ChristophU
抗精神病药对 EOS 的治疗有效。鉴于抗精神病药物之间缺乏疗效差异（除了治疗难治性 EOS 的氯氮平外），我们建议需要考虑耐受性来指导抗精神病药物的选择。迫切需要进一步和长期的疗效和有效性研究，还应探索药物和非药物增强策略。
Antipsychotics are efficacious in the treatment of EOS. Given the lack of efficacy differences between antipsychotics (except for clozapine for treatment-refractory EOS), we propose that tolerability considerations need to guide choice of antipsychotics. Further and longer-term efficacy and effectiveness studies are urgently needed that should also explore pharmacologic and nonpharmacologic augmentation strategies.