Gut Microbiome in Anesthesiology and Pain Medicine.
Gut Microbiome in Anesthesiology and Pain Medicine.
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麻醉学和疼痛医学中的肠道微生物组。
DOI：
10.1097/aln.0000000000004204
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发表时间：
2022-07-01
期刊：
影响因子：
8.8
通讯作者：
Shen, Shiqian
中科院分区：
文献类型：
--
作者：
Minerbi, Amir;Shen, Shiqian
肠道微生物组在人类健康和疾病中起着关键作用。最近的研究表明，它也可能与慢性疼痛和术后疼痛结局有关。在动物模型中，全身麻醉后肠道微生物组的组成发生变化，并影响宿主对药物的反应，包括麻醉剂和阿片类药物。在人类中，肠道微生物组与术后疼痛和神经认知障碍的发展有关。此外，肠道微生物组的组成与疼痛状况相关，包括内脏痛、伤害性疼痛、复杂性局部疼痛综合征和头痛，部分原因是循环细菌衍生代谢物的浓度改变。此外，动物研究表明，肠道微生物组通过免疫调节机制在神经性疼痛中发挥关键作用。在这里，我们回顾了人类肠道微生物组的基本概念及其与宿主的相互作用，并提供了将肠道微生物组与麻醉学，重症监护和疼痛医学联系起来的证据的全面概述。肠道微生物组越来越被认为是涉及“肠-脑轴”的关键因素。这篇叙述性综述总结和评价了围手术期和疼痛医生和研究人员在肠道微生物组方面的最新进展。
The gut microbiome plays critical roles in human health and disease. Recent studies suggest it may also be associated with chronic pain and postoperative pain outcomes. In animal models, the composition of the gut microbiome changes following general anesthesia, and affects the host response to medications, including anesthetics and opioids. In humans, the gut microbiome is associated with the development of postoperative pain and neurocognitive disorders. Additionally, the composition of the gut microbiome has been associated with pain conditions including visceral pain, nociplastic pain, complex regional pain syndrome and headaches, partly through altered concentration of circulating bacterial-derived metabolites. Furthermore, animal studies demonstrate a critical role of the gut microbiome in neuropathic pain, via immunomodulatory mechanisms. Here, we review basic concepts of the human gut microbiome and its interactions with the host, and provide a comprehensive overview of the evidence linking the gut microbiome to anesthesiology, critical care and pain medicine. Gut microbiome is increasingly recognized as a key factor implicated in the ‘gut-brain axis’. This narrative review summarizes and appraises recent advances in gut microbiome for perioperative and pain physicians and researchers.