Antibacterial and Functional Properties Enhancement of Mesoporous Calcium-Silicate Nanoparticles by Coupling with Quaternary Ammonium Chloride
Antibacterial and Functional Properties Enhancement of Mesoporous Calcium-Silicate Nanoparticles by Coupling with Quaternary Ammonium Chloride
复制标题
季铵氯化物偶联增强介孔硅酸钙纳米粒子的抗菌和功能性能
DOI：
10.1166/nnl.2017.2490
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发表时间：
2017-09
影响因子：
--
通讯作者：
Wei Fan
中科院分区：
文献类型：
--
作者：
Qihang Fan;Yanyun Li;Tengjiao Ma;Yujie Wu;Bin Shi;Wei Fan
Apical bone defect is one of the most common consequences of chronic apical periodontitis. The present study aimed to enhance the antibacterial and functional properties such as ions release, biocompatibility, cytotoxicity, and mineralization of the mesoporous calcium-silicate nanoparticles (MCSNs) by incorporation with quaternary ammonium compounds (QAC) using a mixing-coupling method. The results revealed that QAC molecules were successfully modified onto the MCSNs by the mixing-coupling method. These QAC modified MCSNs (M-QAC) nanoparticles have sub-globular structures (diameters 100 to 200 nm) and pores inside the nanoparticles (pore sizes 2 to 4 nm), with stable pH during 9 days (10 for MCSNs and 9.5 for M-QAC). The M-QAC nanoparticles exhibited significantly lower release of Ca2+ and SiO3 2– ions than MCSNs. Neither MCSNs nor M-QAC nanoparticles synthesized in this study showed any cytotoxic effect on MC3T3-E1 cells. The functionalized nanoparticles demonstrated significant inhibitory effects on bacterial attachment, without compromising the proliferation ability of MC3T3-E1 cells. Moreover, in simulated body fluids, massive mineralization and crystallization were observed on the surfaces of compacted nanoparticle tablets. In conclusion, the M-QAC nanoparticles synthesized in this study can be used as an effective filling material for infected apical bone lesions of human teeth.
