MR-elastography reveals degradation of tissue integrity in multiple sclerosis
MR-elastography reveals degradation of tissue integrity in multiple sclerosis
复制标题
DOI：
10.1016/j.neuroimage.2009.06.018
复制
发表时间：
2010-02-01
期刊：
影响因子：
5.7
通讯作者：
Sack, Ingolf
中科院分区：
文献类型：
--
作者：
Wuerfel, Jens;Paul, Friedemann;Sack, Ingolf
在多发性硬化症（MS）中，越来越多的人认识到弥漫性脑实质损伤超过局灶性炎症，从疾病的一开始就存在，尽管对常规成像技术来说是隐匿的，但可能是永久性神经功能障碍的主要原因。微妙的组织变化显着影响的刚度和内部摩擦，这-在更容易接近的器官比大脑-传统上是通过手动触诊在临床exam. The大脑，然而，从我们的触觉保护，因此我们目前的知识油脑粘弹性是非常有限的生物力学特性。我们开发了一种临床上可行的磁共振弹性成像设置敏感的脑实质生物力学特性的微妙变化。对45名MS患者的调查显示，P
In multiple sclerosis (MS), diffuse brain parenchymal damage exceeding focal inflammation is increasingly recognized to be present from the very onset of the disease, and, although occult to conventional imaging techniques, may present a major Cause of permanent neurological disability. Subtle tissue alterations significantly influence biomechanical properties given by stiffness and internal friction, that - in more accessible organs than the brain - are traditionally assessed by manual palpation during the clinical exam. The brain, however, is protected from our sense of touch, and thus Our current knowledge oil cerebral viscoelasticity is very limited. We developed a clinically feasible magnetic resonance elastography setup sensitive to subtle alterations of brain parenchymal biomechanical properties. Investigating 45 MS patients revealed a significant decrease (13%. P