Health-related quality of life in female long-term colorectal cancer survivors
Health-related quality of life in female long-term colorectal cancer survivors
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DOI：
10.1634/theoncologist.8-4-342
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发表时间：
2003-01-01
期刊：
影响因子：
5.8
通讯作者：
Newcomb, PA
中科院分区：
文献类型：
--
作者：
Trentham-Dietz, A;Remington, PL;Newcomb, PA
虽然结直肠癌治疗后存活的妇女人数正在增加，但对长期存活者的生活质量知之甚少。本文提出的分析的目的是描述女性长期结直肠癌幸存者的整体健康相关的生活质量和可能改变其生活质量水平的因素。对1990-1991年诊断为结直肠癌的726名威斯康星州妇女进行了再接触。在1999年存活的443名妇女中，307名（69%）完成了随访问卷，包括医疗结局研究简表36健康状况调查，该调查由36个项目组成，产生9个领域量表评分和2个汇总评分：身体成分汇总评分和心理成分汇总评分。平均随访时间为9年（范围7-11），随访时的平均年龄为72岁（范围43-85）。在随访时，年龄较大、合并症数量较多和体重较大的参与者的平均身体成分总分较低。合并症数量较多的参与者的平均精神健康总评也较低。在所有8个领域量表中观察到与合并症程度相关的差异。结直肠癌的女性长期幸存者报告的健康相关的生活质量与一般人群中年龄相仿的女性相当。这些数据表明，从长期来看，与初始结直肠癌诊断相关的因素相比，衰老、体重和慢性疾病等因素在决定身心健康方面发挥着更重要的作用。
Although the number of women who survive treatment for colorectal cancer is growing, little is known about the quality of life of long-term survivors. The purpose of analyses presented in this paper is to describe the overall health-related quality of life of female long-term colorectal cancer survivors and the factors that may modify their levels of quality of life. A population-based sample of 726 Wisconsin women diagnosed with colorectal cancer from 1990-1991 was recontacted. Of the 443 women alive in 1999, 307 (69%) completed a follow-up questionnaire including the Medical Outcomes Study Short-Form 36 Health Status Survey, which is comprised of 36 items that generate nine domain scale scores and two summary scores: the Physical Component Summary score and the Mental Component Summary score. The mean follow-up was 9 years (range 7-11), and the mean age at follow-up was 72 years (range 43-85). The mean Physical Component Summary score was lower for participants with greater ages, greater numbers of comorbidities, and greater body masses at the time of follow-up. The mean Mental Component Summary score also was lower for participants with greater numbers of comorbidities. Differences associated with degree of comorbidity were observed for all eight domain scales. Female long-term survivors of colorectal cancer appear to report health-related quality of life comparable with that of similarly aged women in the general population. These data suggest that, over the long term, factors attributable to aging, body weight, and chronic medical conditions play more dominant roles in determining physical and mental health than factors related to the initial colorectal cancer diagnosis.