Coast-to-Coast Spread of SARS-CoV-2 during the Early Epidemic in the United States
Coast-to-Coast Spread of SARS-CoV-2 during the Early Epidemic in the United States
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DOI：
10.1016/j.cell.2020.04.021
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发表时间：
2020-05-28
期刊：
影响因子：
64.5
通讯作者：
Grubaugh, Nathan D.
中科院分区：
文献类型：
--
作者：
Fauver, Joseph R.;Petrone, Mary E.;Grubaugh, Nathan D.
新型冠状病毒SARS-CoV-2于二零二零年一月首次在美国西北太平洋地区发现，随后于三月初在所有50个州发现COVID-19疫情。为了揭示SARS-CoV-2在美国的传播来源和传播模式，我们对康涅狄格州早期报告的COVID-19患者的9个病毒基因组进行了测序。我们的系统发育分析将这些基因组中的大多数与从华盛顿州测序的病毒放在一起。通过将我们的基因组数据与国内和国际旅行模式相结合，我们表明，康涅狄格州早期的SARS-CoV-2传播可能是由国内引入驱动的。此外，尽管我们估计了联邦旅行限制的影响，但到3月中旬，康涅狄格州国内进口的风险超过了国际进口的风险。这项研究提供了SARS-CoV-2在美国广泛持续传播的证据，并强调了地方监测的迫切需要。
The novel coronavirus SARS-CoV-2 was first detected in the Pacific Northwest region of the United States in January 2020, with subsequent COVID-19 outbreaks detected in all 50 states by early March. To uncover the sources of SARS-CoV-2 introductions and patterns of spread within the United States, we sequenced nine viral genomes from early reported COVID-19 patients in Connecticut. Our phylogenetic analysis places the majority of these genomes with viruses sequenced from Washington state. By coupling our genomic data with domestic and international travel patterns, we show that early SARS-CoV-2 transmission in Connecticut was likely driven by domestic introductions. Moreover, the risk of domestic importation to Connecticut exceeded that of international importation by mid-March regardless of our estimated effects of federal travel restrictions. This study provides evidence of widespread sustained transmission of SARS-CoV-2 within the United States and highlights the critical need for local surveillance.